2023
Cardiothoracic complications of immune checkpoint inhibitors
Gosangi B, Wang Y, Rubinowitz A, Kwan J, Traube L, Gange C, Bader A. Cardiothoracic complications of immune checkpoint inhibitors. Clinical Imaging 2023, 102: 98-108. PMID: 37659356, DOI: 10.1016/j.clinimag.2023.08.001.Peer-Reviewed Educational MaterialsConceptsImmune checkpoint inhibitorsICI therapyCheckpoint inhibitorsOverall survivalTumor responseAdverse effectsDevelopment of irAEsNovel adverse effectsImproved overall survivalOverall patient outcomesICI administrationHematologic malignanciesPatient outcomesSolid tumorsIrAEsCancer treatmentGreater mortalityComplicationsTherapySurvivalInhibitorsMyocarditisPneumonitisPatientsMalignancy
2009
Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance
Piazza N, Gosangi B, Devilla S, Arking R, Wessells R. Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance. PLOS ONE 2009, 4: e5886. PMID: 19517023, PMCID: PMC2691613, DOI: 10.1371/journal.pone.0005886.Peer-Reviewed Original ResearchConceptsInvertebrate genetic model systemGenetic model systemUnbiased genetic screenGenetic screenDrosophila melanogasterGenetic basisYoung fliesMitochondrial efficiencyAmount of proteinFliesExercise training modelPhysiological responsesModel systemGenetic therapiesMelanogasterMechanized platformNegative geotaxisLociProteinPhenotypeResponseGreat promiseLipidsAge-related declineMajor source