Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses
Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB. Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses. The Journal Of Immunology 2009, 183: 6989-6997. PMID: 19890046, PMCID: PMC2920602, DOI: 10.4049/jimmunol.0901386.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell LineDEAD Box Protein 58DEAD-box RNA HelicasesEpithelial CellsGene ExpressionHumansInterferon-Induced Helicase, IFIH1Picornaviridae InfectionsReceptors, ImmunologicReceptors, Pattern RecognitionRespiratory MucosaReverse Transcriptase Polymerase Chain ReactionRhinovirusRNA, Double-StrandedRNA, Small InterferingSignal TransductionToll-Like Receptor 3ConceptsIL-8/CXCL8RV-1BChronic obstructive pulmonary disease exacerbationsObstructive pulmonary disease exacerbationsGM-CSFMelanoma differentiation-associated geneAirway epithelial cell responsesIFN-lambda1Pulmonary disease exacerbationsBEAS-2B human bronchial epithelial cellsRetinoic acid-inducible geneToll/IL-1RHuman bronchial epithelial cellsPattern recognition receptorsEpithelial cell responsesUV-irradiated virusBronchial epithelial cellsAcid-inducible geneBEAS-2B cellsDisease exacerbationTLR-3IFN response factorsCommon coldIL-1RIFN expression