Bo Tao, BE, PhD
Associate Research Scientist in PathologyDownloadHi-Res Photo
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Pathology
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About
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Associate Research Scientist in Pathology
Appointments
Education & Training
- PhD
- Zhejiang University, Basic medical sciences/Pathology & Pathophysiology (2014)
- BE
- Zhejiang University of Technology, Biological and environmental engineering/Biological Engineering (2007)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Bo Tao's published research.
Publications Timeline
A big-picture view of Bo Tao's research output by year.
William Sessa, PhD
Anne Eichmann, PhD
Barbora Salovska, PhD
Carlos Fernandez-Hernando, PhD
Chiang-Shan Ray Li, MD, PhD
Ewa Folta-Stogniew, PhD, MSc
23Publications
243Citations
Publications
2024
Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Sweeney J, Gong Q, Lui S. Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia. Cerebral Cortex 2024, 34: bhae402. PMID: 39375878, DOI: 10.1093/cercor/bhae402.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDorsal attention networkFirst-episode schizophreniaNetwork switching rateAntipsychotic treatmentSchizophrenia patientsReduction of negative symptomsResting-state functional magnetic resonance imaging dataUntreated first-episode schizophreniaDrug-naive schizophrenia patientsHealthy controlsFunctional magnetic resonance imaging dataEarly-stage schizophreniaFirst-episode drug-naive schizophrenia patientsInferior parietal lobuleFunctional network activityBrain network activityMagnetic resonance imaging dataNetwork activityAntipsychotic medicationNegative symptomsParietal lobuleAcute psychosisParietal regionsSchizophreniaMultilayer network analysisProgressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchConceptsHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunctionMultivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
Zhao Q, Gao Z, Yu W, Xiao Y, Hu N, Wei X, Tao B, Zhu F, Li S, Lui S. Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia. Schizophrenia 2024, 10: 62. PMID: 39004627, PMCID: PMC11247086, DOI: 10.1038/s41537-024-00482-0.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCortical surface areaSubcortical volumesMedicated individualsFirst-episode schizophrenia sampleCortical thicknessBrain-behavior profilesAnterior cingulate cortexRight parahippocampal gyrusVerbal fluency testInferior parietal lobuleMultiple cognitive domainsVerbal memory performanceSample of individualsAntipsychotic doseAntipsychotic medicationPsychopathological symptomsCingulate cortexNeurobiological basisFluency testRight caudateMemory performanceParietal lobuleCognitive domainsIllness durationApplications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility
Sun H, Liu N, Qiu C, Tao B, Yang C, Tang B, Li H, Zhan K, Cai C, Zhang W, Lui S. Applications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility. Journal Of Magnetic Resonance Imaging 2024 PMID: 38946400, DOI: 10.1002/jmri.29470.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingTreatment outcome of schizophreniaOutcome of schizophreniaSevere mental illnessSchizophrenia patientsSchizophreniaIllness onsetPredicting symptomsBrain abnormalitiesClinical utilityMental illnessTreatment outcomesDecades of researchFindings of magnetic resonance imagingScreening high-risk individualsLife of affected individualsHigh-risk individualsPromote clinical translationResonance imagingIncreased mortality rateResponse processApplication of magnetic resonance imagingSymptomsPrognostic toolResearch findingsAltered cerebral white matter network topology and cognition in children with obstructive sleep apnea
Chen F, Fu Y, Tang B, Tao B, Wang Y, Huang Y, Chen T, Yu C, Jiang C, Lui S, Cai X, Lu Y, Yan Z. Altered cerebral white matter network topology and cognition in children with obstructive sleep apnea. Sleep Medicine 2024, 118: 63-70. PMID: 38613858, DOI: 10.1016/j.sleep.2024.03.038.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsObstructive apnea-hypopnea indexWhite matter networksVerbal Comprehension IndexNon-OSA childrenEvidence of impaired cognitive functionRight temporal poleSuperior temporal gyrusImpaired cognitive functionBrain white matter networkHierarchical linear regressionApnea-hypopnea indexObstructive sleep apneaNeuroimaging evidenceTemporal gyrusTemporal poleBrain regionsCognitive testsCognitive functionMediation analysisTemporal lobeCognitive impairmentChild's brainNetwork propertiesSleep apneaComprehensive indexIs unilateral cerebellum sufficient? Insights from new cases of cerebellar agenesis and literature review
Deng D, Tao B, Yuan Y, Ao Y, Qiu L. Is unilateral cerebellum sufficient? Insights from new cases of cerebellar agenesis and literature review. Psychoradiology 2024, 4: kkae012. PMID: 39022191, PMCID: PMC11253423, DOI: 10.1093/psyrad/kkae012.Peer-Reviewed Original ResearchConceptsCerebellar agenesisFunctional magnetic resonance imagingCerebellar diseaseNon-motor functionsCase of cerebellar agenesisNon-motor domainsMild cognitive impairmentMotor functionSocial behaviorCognitive impairmentPrevent deficitsMild depressionClinical manifestationsSevere autismMotor deficitsCerebellumMagnetic resonance imagingStructural imagingDeficitsImpairmentBrainResonance imagingMotorCerebellar developmentReview pertinent literature
2023
CT Hyperdense Lesions after Endovascular Therapy in Acute Ischemic Stroke: Imaging Findings and Clinical Significance
Yu W, Xia C, Tao B, Xiao Y, Gao Z, Zhu F, Zhao Q, Lui S. CT Hyperdense Lesions after Endovascular Therapy in Acute Ischemic Stroke: Imaging Findings and Clinical Significance. Cerebrovascular Diseases 2023, 53: 607-617. PMID: 37989121, DOI: 10.1159/000535369.Peer-Reviewed Original ResearchConceptsNon-contrast CTAcute ischemic strokeFollow-up protocolEndovascular therapyContrast extravasationHyperdense lesionHemorrhagic transformationTreated with endovascular therapyStandardized follow-up protocolIschemic strokeDual-energy CTSusceptibility weighted imagingClinical outcomesImaging findingsClinical significanceRadiographic findingsClinical evaluationPostoperative phenomenonExtravasationLesionsAn optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
Zhou W, Li W, Wang S, Salovska B, Hu Z, Tao B, Di Y, Punyamurtula U, Turk B, Sessa W, Liu Y. An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells. Nature Communications 2023, 14: 3803. PMID: 37365174, PMCID: PMC10293293, DOI: 10.1038/s41467-023-39514-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPhosphorylation sitesSerine/threonine kinase AktMass spectrometry-based phosphoproteomicsThreonine kinase AktAkt-dependent phosphorylationAberrant Akt activationEndothelial cellsKinase substrateKinase AktCell signalingPhosphorylation profilePhenotypic outcomesDownstream signalingAkt activationAkt1 phosphorylationHuman diseasesSystem-level analysisAKT1Vascular endothelial cellsRich resourcePhosphorylationSignalingGrowth factorAktCellsGenetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul P, Lee W, Fernandez-Hernando C, Eichmann A, Sessa W. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice. Nature Cardiovascular Research 2023, 2: 438-448. PMID: 39196046, PMCID: PMC11358031, DOI: 10.1038/s44161-023-00266-2.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLDL transcytosisLDL receptor knockout miceReceptor knockout miceAtherosclerotic cardiovascular diseaseLow-density lipoprotein accumulationHigh-fat dietPromising therapeutic strategyTherapeutic neutralizationMacrophage infiltrationTriglyceride levelsLDL entryCardiovascular diseaseSelective monoclonal antibodiesLipoprotein accumulationTherapeutic strategiesKnockout micePlaque formationAtherosclerosis initiationType 1Genetic deletionArterial wallMonoclonal antibodiesEndothelial cellsLDL accumulationMice
2022
Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes
Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes. Hepatology Communications 2022, 6: 2748-2764. PMID: 35852334, PMCID: PMC9512452, DOI: 10.1002/hep4.2042.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLipid raftsCaveolin-1Intact lipid raftsType 3 inositol trisphosphate receptorApical regionC-terminal amino acidsTrisphosphate receptor type 3Madin-Darby canine kidney cellsCanine kidney cellsFluorescence microscopy techniquesInositol trisphosphate receptorApical localizationTrisphosphate receptorHeavy chain 9Molecular determinantsChemical disruptionAmino acidsITPR3RaftsKidney cellsIntracellular CaFinal common eventReceptor type 3Release channelMYH9
Academic Achievements & Community Involvement
activity Environmental Pollution
Journal ServiceReviewerDetails2016 - Presentactivity The Science of the Total Environment
Journal ServiceReviewerDetails2016 - Presentactivity Engineering
Journal ServiceReviewerDetails2021 - Presentactivity Chemosphere
Journal ServiceReviewerDetails2016 - Presentactivity Environmental Toxicology
Journal ServiceReviewerDetails2016 - Present