TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
Streiff M, Corbin A, Ahmad A, Hunter C, Sachse F. TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes. Frontiers In Physiology 2022, 13: 1056657. PMID: 36620209, PMCID: PMC9817106, DOI: 10.3389/fphys.2022.1056657.Peer-Reviewed Original ResearchNeonatal rat ventricular myocytesTransient receptor potentialTRPC1 channelsTRPC1 expressionCardiac diseaseReceptor potentialSarcoplasmic reticulum calcium leakAdenoviral transfectionRat ventricular myocytesSarco/endoplasmic reticulum CaPermeable ion channelsPhysiological roleSR leakPharmacological therapyEndoplasmic reticulum CaCalcium leakMechanosensitive modulationVentricular myocytesWestern blotReticulum CaRT-qPCRTRPC1CardiomyocytesDisease developmentSignificant reduction