The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells
Xu D, Allsop S, Witherspoon S, Snider J, Yeh J, Fiordalisi J, White C, Williams D, Cox A, Baines A. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis 2011, 32: 488-495. PMID: 21262926, PMCID: PMC3066419, DOI: 10.1093/carcin/bgr007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBcl-Associated Death ProteinCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p27HumansNeoplasm InvasivenessPancreatic NeoplasmsPhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-pim-1Proto-Oncogene Proteins p21(ras)Radiation ToleranceRas ProteinsSignal TransductionConceptsShRNA-mediated suppressionK-Ras signalingPim-1 expressionPancreatic ductal adenocarcinoma cell linesPim-1 kinasePro-apoptotic protein BadCell growthOncogenic K-Ras signalingK-rasPim-1 protein levelsCyclin-dependent kinase inhibitor p27Kip1Immortalized cell modelGrowth transformationHuman pancreatic ductal adenocarcinoma cellsCell linesPancreatic ductal adenocarcinomaPim-1Pancreatic ductal adenocarcinoma cell growthMutant K-rasPim-1 activityPim-1 proteinProtein BadOncogenic K-RasPancreatic ductal adenocarcinoma cellsKinase activity