Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein–Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling
Tsiperson V, Gruber R, Goldberg M, Jordan A, Weinger J, Macian F, Shafit-Zagardo B. Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein–Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling. The Journal Of Immunology 2013, 190: 1528-1539. PMID: 23335751, PMCID: PMC3564598, DOI: 10.4049/jimmunol.1201387.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsChronic DiseaseEncephalomyelitis, Autoimmune, ExperimentalGenetic Predisposition to DiseaseInflammation MediatorsLumbosacral RegionMaleMiceMice, Inbred C57BLMice, KnockoutMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsProto-Oncogene Proteins c-aktSeverity of Illness IndexSignal TransductionSpinal CordConceptsExperimental autoimmune encephalomyelitisSpinal cordAutoimmune encephalomyelitisWT miceImmune cellsBone marrow-derived immune cellsRegulatory T cell-mediated suppressionAcute experimental autoimmune encephalomyelitisT cell-mediated suppressionWT spinal cordsRegulatory T cellsBone marrow chimerasCell-mediated suppressionProtection of miceMyelin oligodendrocyte glycoproteinWild-type miceIFN-γ mRNABone marrow cellsAkt3 signalingMore demyelinationQuantitative RT-PCRCNS damageIL-17Axonal injuryClinical scores