2020
CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking
Pluchino N, Mamillapalli R, Shaikh S, Habata S, Tal A, Gaye M, Taylor HS. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking. Journal Of Cellular And Molecular Medicine 2020, 24: 2464-2474. PMID: 31904910, PMCID: PMC7028867, DOI: 10.1111/jcmm.14933.Peer-Reviewed Original ResearchConceptsCXCR7 antagonistLesion sizePro-inflammatory cytokine productionBone marrow-derived cellsNon-hormonal therapiesMouse bone marrow transplantation modelBone marrow transplantation modelBone marrow cell migrationMarrow-derived cellsProgression of endometriosisEndometriosis implantsEndometrial effectsAntagonist treatmentEndometriotic lesionsCytokine productionEndometrial physiologyStem cell recruitmentEutopic endometriumTransplantation modelCell recruitmentNull miceCell traffickingEndometriosisEpithelial cell fateCXCR4
2019
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitorsEndometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesions
2018
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis
Li F, Alderman MH, Tal A, Mamillapalli R, Coolidge A, Hufnagel D, Wang Z, Neisani E, Gidicsin S, Krikun G, Taylor HS. Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 2018, 36: 881-890. PMID: 29450941, PMCID: PMC5992028, DOI: 10.1002/stem.2804.Peer-Reviewed Original ResearchConceptsSerum CXCL12 levelsCXCL12 levelsEndometrial tissueEndometriosis lesionsHematogenous disseminationMesenchymal stem cell biomarkersCXCL12/CXCR4 axisStem cellsTreatment of endometriosisSham control miceEndometrial stem cellsHematopoietic stem cell markersStem cell biomarkersStem cell markersSpontaneous endometriosisRetrograde menstruationControl miceExperimental endometriosisRecipient miceCXCR4 axisLung tissueEndometriosisPeritoneal cavityDsRed miceBlood of animals
2017
Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause: Ancillary Study of the Kronos Early Estrogen Prevention Study (KEEPS)
Taylor HS, Tal A, Pal L, Li F, Black DM, Brinton EA, Budoff MJ, Cedars MI, Du W, Hodis HN, Lobo RA, Manson JE, Merriam GR, Miller VM, Naftolin F, Neal-Perry G, Santoro NF, Harman SM. Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause: Ancillary Study of the Kronos Early Estrogen Prevention Study (KEEPS). JAMA Internal Medicine 2017, 177: 1471-1479. PMID: 28846767, PMCID: PMC5710212, DOI: 10.1001/jamainternmed.2017.3877.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAdultDouble-Blind MethodEstradiolEstrogen Replacement TherapyEstrogensEstrogens, Conjugated (USP)FemaleFollow-Up StudiesGlucuronatesHumansMiddle AgedPostmenopauseProgesteroneProgestinsProspective StudiesPsychiatric Status Rating ScalesQuality of LifeRisk FactorsSexual Dysfunction, PhysiologicalTime FactorsWomen's HealthConceptsKronos Early Estrogen Prevention StudyLow sexual functionTransdermal estrogen therapySexual functionAncillary studiesEstrogen therapyPostmenopausal womenPrevention StudyT-E2Female Sexual Function InventoryOral conjugated equine estrogenOverall scoreLower FSFI scoresEarly postmenopausal womenMenopausal hormone therapyPlacebo-controlled trialOral micronized progesteroneConjugated equine estrogensSexual Function InventoryLast menstrual periodEffects of OralQuality of lifeProportion of womenSymptoms of distressMicronized progesterone
2016
Rescue in vitro maturation (IVM) of immature oocytes in stimulated cycles in women with low functional ovarian reserve (LFOR).
Lee HJ, Barad DH, Kushnir VA, Shohat-Tal A, Lazzaroni-Tealdi E, Wu YG, Gleicher N. Rescue in vitro maturation (IVM) of immature oocytes in stimulated cycles in women with low functional ovarian reserve (LFOR). Endocrine 2016, 52: 165-71. PMID: 26419849, DOI: 10.1007/s12020-015-0744-1.Peer-Reviewed Original Research
2015
More on the conversion of DHEA to testosterone.
Shohat-Tal A, Sen A, Barad DH, Kushnir VA, Gleicher N. More on the conversion of DHEA to testosterone. Nature Reviews. Endocrinology 2015, 11: 521. PMID: 26170026, DOI: 10.1038/nrendo.2015.108.Peer-Reviewed Original ResearchGenetics of androgen metabolism in women with infertility and hypoandrogenism.
Shohat-Tal A, Sen A, Barad DH, Kushnir V, Gleicher N. Genetics of androgen metabolism in women with infertility and hypoandrogenism. Nature Reviews. Endocrinology 2015, 11: 429-41. PMID: 25942654, DOI: 10.1038/nrendo.2015.64.Peer-Reviewed Original Research
2014
A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: impact on endometrial thickness and clinical pregnancy rates.
Barad DH, Yu Y, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, Gleicher N. A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: impact on endometrial thickness and clinical pregnancy rates. Fertility And Sterility 2014, 101: 710-5. PMID: 24424357, DOI: 10.1016/j.fertnstert.2013.12.016.Peer-Reviewed Original ResearchUtilizing FMR1 gene mutations as predictors of treatment success in human in vitro fertilization.
Kushnir VA, Yu Y, Barad DH, Weghofer A, Himaya E, Lee HJ, Wu YG, Shohat-Tal A, Lazzaroni-Tealdi E, Gleicher N. Utilizing FMR1 gene mutations as predictors of treatment success in human in vitro fertilization. PloS One 2014, 9: e102274. PMID: 25019151, PMCID: PMC4096763, DOI: 10.1371/journal.pone.0102274.Peer-Reviewed Original Research
2013
FMR1-dependent variability of ovarian aging patterns is already apparent in young oocyte donors.
Gleicher N, Kim A, Barad DH, Shohat-Tal A, Lazzaroni E, Michaeli T, Lee HJ, Kushnir VA, Weghofer A. FMR1-dependent variability of ovarian aging patterns is already apparent in young oocyte donors. Reproductive Biology And Endocrinology : RB&E 2013, 11: 80. PMID: 23948096, PMCID: PMC3751312, DOI: 10.1186/1477-7827-11-80.Peer-Reviewed Original ResearchIs androgen production in association with immune system activation potential evidence for existence of a functional adrenal/ovarian autoimmune system in women?
Gleicher N, Weghofer A, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, Barad DH. Is androgen production in association with immune system activation potential evidence for existence of a functional adrenal/ovarian autoimmune system in women? Reproductive Biology And Endocrinology : RB&E 2013, 11: 58. PMID: 23805952, PMCID: PMC3700837, DOI: 10.1186/1477-7827-11-58.Peer-Reviewed Original ResearchTransforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation
Tal R, Seifer DB, Shohat-Tal A, Grazi RV, Malter HE. Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation. Fertility And Sterility 2013, 100: 538-543. PMID: 23684116, DOI: 10.1016/j.fertnstert.2013.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, CDCase-Control StudiesEndoglinFemaleFertilization in VitroFollicular FluidHumansInfertility, FemaleOvarian Hyperstimulation SyndromeOvulation InductionPolycystic Ovary SyndromeReceptors, Cell SurfaceSperm Injections, IntracytoplasmicTransforming Growth Factor beta1UltrasonographyYoung AdultConceptsPolycystic ovarian syndromeSerum soluble endoglinDay of hCGSoluble endoglinFollicular fluidTGF-β1Oocyte retrievalOvarian stimulationHCG administrationControl womenDay 3Pathogenesis of PCOSNon-PCOS control groupProspective case-control studyNon-PCOS controlsSerum TGF-β1Non-PCOS womenPolycystic ovary syndromeTGF-β1 levelsReproductive technology unitCase-control studyGrowth factor-β1Day of retrievalOvarian hyperstimulationOvarian syndromeClinical relevance of combined FSH and AMH observations in infertile women.
Gleicher N, Kim A, Kushnir V, Weghofer A, Shohat-Tal A, Lazzaroni E, Lee HJ, Barad DH. Clinical relevance of combined FSH and AMH observations in infertile women. The Journal Of Clinical Endocrinology And Metabolism 2013, 98: 2136-45. PMID: 23533225, DOI: 10.1210/jc.2013-1051.Peer-Reviewed Original ResearchHypoandrogenism in association with diminished functional ovarian reserve.
Gleicher N, Kim A, Weghofer A, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, Barad DH. Hypoandrogenism in association with diminished functional ovarian reserve. Human Reproduction (Oxford, England) 2013, 28: 1084-91. PMID: 23427231, DOI: 10.1093/humrep/det033.Peer-Reviewed Original ResearchStarting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR).
Gleicher N, Kim A, Weghofer A, Shohat-Tal A, Lazzaroni E, Lee HJ, Barad DH. Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR). Journal Of Assisted Reproduction And Genetics 2013, 30: 49-62. PMID: 23212832, PMCID: PMC3553353, DOI: 10.1007/s10815-012-9890-z.Peer-Reviewed Original Research
2011
Cell cycle regulators interact with pathways that modulate microtubule stability in Saccharomyces cerevisiae.
Shohat-Tal A, Eshel D. Cell cycle regulators interact with pathways that modulate microtubule stability in Saccharomyces cerevisiae. Eukaryotic Cell 2011, 10: 1705-13. PMID: 22037179, PMCID: PMC3232728, DOI: 10.1128/EC.05215-11.Peer-Reviewed Original Research