Performance of a Multianalyte ‘Rule-Out’ Assay in Pregnant Individuals With Suspected Preeclampsia
Costantine MM, Sibai B, Bombard AT, Sarno M, West H, Haas DM, Tita AT, Paidas MJ, Clark EAS, Boggess K, Grotegut C, Grobman W, Su EJ, Burd I, Saade G, Chavez MR, Paglia MJ, Merriam A, Torres C, Habli M, Macones G, Wen T, Bofill J, Palatnik A, Edwards RK, Haeri S, Oberoi P, Mazloom A, Cooper M, Lockton S, Hankins GD. Performance of a Multianalyte ‘Rule-Out’ Assay in Pregnant Individuals With Suspected Preeclampsia. Hypertension 2022, 79: 1515-1524. PMID: 35545947, PMCID: PMC9172903, DOI: 10.1161/hypertensionaha.122.19038.Peer-Reviewed Original ResearchConceptsDays of enrollmentPregnant individualsStudy cohortNegative predictive value 95.0Multivariate Cox regression modelHigh negative predictive valueMulticenter cohort studyIncidence of preeclampsiaCox regression modelTime of enrollmentNegative predictive valueNegative control groupNegative likelihood ratioCohort studyPreeclampsiaBaseline evaluationPrimary analysisControl groupPredictive valueWeeksModerate sensitivityCohortEnrollmentLikelihood ratioRegression models