2018
New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice
Bagdas D, Alkhlaif Y, Jackson A, Carroll FI, Ditre JW, Damaj MI. New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice. Neuropharmacology 2018, 138: 72-79. PMID: 29860196, PMCID: PMC6054891, DOI: 10.1016/j.neuropharm.2018.05.025.Peer-Reviewed Original ResearchConceptsEffects of vareniclineNicotine withdrawal signsNicotine rewardΑ5 nAChRWithdrawal signsHigh doseKnockout miceΒ2-nAChRsNicotine withdrawal-induced hyperalgesiaAdministration of vareniclineWithdrawal-induced hyperalgesiaΑ7 knockout miceDose-related mannerNicotinic acetylcholine receptorsΑ5 knockout micePlace preference testVarenicline doseCessation treatmentNicotine withdrawalSomatic signsVareniclineΑ7 nAChRsMouse modelCPP testNicotinic subtypes
2017
Reversal of Nicotine Withdrawal Signs Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Male Mice
Hamouda AK, Jackson A, Bagdas D, Damaj M. Reversal of Nicotine Withdrawal Signs Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Male Mice. Nicotine & Tobacco Research 2017, 20: 903-907. PMID: 29059422, PMCID: PMC5991208, DOI: 10.1093/ntr/ntx183.Peer-Reviewed Original ResearchConceptsNicotine withdrawal symptomsSpontaneous nicotine withdrawalNicotine withdrawal signsNicotine withdrawalWithdrawal symptomsPositive allosteric modulatorsCessation aidWithdrawal signsMale miceMouse modelAllosteric modulatorsNicotinic acetylcholine receptor agonistNAChR-positive allosteric modulatorsAcetylcholine receptor agonistDose-dependent reversalICR male miceΑ4β2 nicotinic acetylcholine receptorsPositive allosteric modulationAnxiety-like behaviorNicotinic acetylcholine receptorsPotential clinical useAcute injectionRelapse rateTobacco smokingDay infusion
2016
Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse
Slater CA, Jackson A, Muldoon PP, Dawson A, O'Brien M, Soll LG, Abdullah R, Carroll FI, Tapper AR, Miles MF, Banks ML, Bettinger JC, Damaj IM. Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. Alcohol Clinical And Experimental Research 2016, 40: 62-72. PMID: 26727524, PMCID: PMC4700556, DOI: 10.1111/acer.12918.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsAzetidinesBody TemperatureCentral Nervous System DepressantsDrug InteractionsEthanolHypnotics and SedativesHypothermiaKetamineMecamylamineMiceMice, Inbred C57BLMice, Inbred DBAMice, KnockoutNicotineNicotinic AgonistsNicotinic AntagonistsPentobarbitalPyridinesReceptors, NicotinicReflex, RightingVareniclineConceptsHypnotic effectsLORR testEtOH intakeReceptor efficacyAcute nicotine injectionDuration of EtOHNicotinic acetylcholine receptor subtypesΑ7 knockout miceNicotinic partial agonist vareniclineAcetylcholine receptor subtypesEffects of nicotineNicotinic antagonist mecamylamineDevelopment of toleranceEffects of EtOHPartial agonist vareniclineAcute injectionAcute nicotineNicotine administrationNicotine exposureAntagonist mecamylamineNicotine injectionHypothermic effectNicotine effectsHypnotic propertiesPharmacological interactions