2016
Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse
Slater CA, Jackson A, Muldoon PP, Dawson A, O'Brien M, Soll LG, Abdullah R, Carroll FI, Tapper AR, Miles MF, Banks ML, Bettinger JC, Damaj IM. Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. Alcohol Clinical And Experimental Research 2016, 40: 62-72. PMID: 26727524, PMCID: PMC4700556, DOI: 10.1111/acer.12918.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsAzetidinesBody TemperatureCentral Nervous System DepressantsDrug InteractionsEthanolHypnotics and SedativesHypothermiaKetamineMecamylamineMiceMice, Inbred C57BLMice, Inbred DBAMice, KnockoutNicotineNicotinic AgonistsNicotinic AntagonistsPentobarbitalPyridinesReceptors, NicotinicReflex, RightingVareniclineConceptsHypnotic effectsLORR testEtOH intakeReceptor efficacyAcute nicotine injectionDuration of EtOHNicotinic acetylcholine receptor subtypesΑ7 knockout miceNicotinic partial agonist vareniclineAcetylcholine receptor subtypesEffects of nicotineNicotinic antagonist mecamylamineDevelopment of toleranceEffects of EtOHPartial agonist vareniclineAcute injectionAcute nicotineNicotine administrationNicotine exposureAntagonist mecamylamineNicotine injectionHypothermic effectNicotine effectsHypnotic propertiesPharmacological interactions
2015
In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (−)-Pyrido[3,4]homotropane [(+)- and (−)-PHT]: (+)-PHT Is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors
Carroll FI, Navarro H, Mascarella SW, Castro AH, Luetje CW, Wageman CR, Marks MJ, Jackson A, Damaj MI. In Vitro and in Vivo Neuronal Nicotinic Receptor Properties of (+)- and (−)-Pyrido[3,4]homotropane [(+)- and (−)-PHT]: (+)-PHT Is a Potent and Selective Full Agonist at α6β2 Containing Neuronal Nicotinic Acetylcholine Receptors. ACS Chemical Neuroscience 2015, 6: 920-926. PMID: 25891987, PMCID: PMC5589077, DOI: 10.1021/acschemneuro.5b00077.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsConditioning, PsychologicalCorpus StriatumDopamineDose-Response Relationship, DrugMaleMice, Inbred ICRMolecular StructureNeuronsNicotinic AgonistsNicotinic AntagonistsPyridinesRatsReceptors, NicotinicSpatial BehaviorSynaptosomesTropanesXenopus laevisConceptsNicotinic antagonistsNeuronal nicotinic acetylcholine receptorsLow efficacy partial agonistSelective full agonistHot plate testNicotinic acetylcholine receptorsPlace preference studiesNicotine rewardAntinociceptive activityΑ3β4 nAChRsΑ7 nAChRsElectrophysiological studiesΑ4β2 nAChRsAcetylcholine receptorsAgonist activityPartial agonistFull agonistNAChRsFull agonismPartial agonismAntagonistΑ4β2MiceReceptor propertiesHigh potency