2022
Non-linear associations between HPA axis activity during infancy and mental health difficulties during early childhood among children in rural Pakistan.
Frost A, Hagaman A, Baranov V, Chung EO, Bhalotra S, Sikander S, Maselko J. Non-linear associations between HPA axis activity during infancy and mental health difficulties during early childhood among children in rural Pakistan. Development And Psychopathology 2022, 35: 2086-2095. PMID: 35959681, PMCID: PMC9922341, DOI: 10.1017/s0954579422000773.Peer-Reviewed Original ResearchConceptsHPA axis activityMental health difficultiesAxis activityHealth difficultiesEarly childhoodHypothalamic pituitary adrenal axis activityPituitary-adrenal axis activitySDQ scoresAdrenal axis activityNon-linear associationLongitudinal cohortDepression trialsQuadratic associationHair cortisolDehydroepiandosteroneRural PakistanMental healthCortisolEarly adversitySignificant quadratic associationDifficulties QuestionnaireLow-resource contextsChildhoodChildrenAssociation
2019
Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
Hagaman A, Gallis JA, Bhalotra S, Baranov V, Turner EL, Sikander S, Maselko J. Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan. PLOS ONE 2019, 14: e0225163. PMID: 31743374, PMCID: PMC6863521, DOI: 10.1371/journal.pone.0225163.Peer-Reviewed Original ResearchConceptsPoor functioningFunctional impairmentPsychosocial characteristicsPerinatal mental healthFunctional trajectoriesPublic health implicationsImportant protective roleHigh functioning groupGroup-based trajectory modeling approachCohort studyThird trimesterFunction recoveryPerinatal periodAssess predictorsChild CohortProtective rolePsychosocial determinantsOne-yearMental healthImportant markerHealth implicationsTrajectory groupsFunctioning groupPregnancyLongitudinal findings