2001
Mechanisms of protein folding
Grantcharova V, Alm E, Baker D, Horwich A. Mechanisms of protein folding. Current Opinion In Structural Biology 2001, 11: 70-82. PMID: 11179895, DOI: 10.1016/s0959-440x(00)00176-7.Peer-Reviewed Original ResearchConceptsEscherichia coli chaperonin GroELNon-native proteinsATP-dependent formationCo-chaperonin GroESLowest free energy pathChaperonin GroELProtein foldingUnfolded proteinsLarge proteinsGroELNative stateNative structureContact orderProteinChaperoninKinetic trapsFoldingChaperonesGroESFree energy pathPolypeptideComplexes
1995
Kinesis of polypeptide during GroEL-mediated folding.
Horwich A, Weissman J, Fenton W. Kinesis of polypeptide during GroEL-mediated folding. Cold Spring Harbor Symposia On Quantitative Biology 1995, 60: 435-40. PMID: 8824417, DOI: 10.1101/sqb.1995.060.01.048.Peer-Reviewed Original Research
1992
Prevention of Protein Denaturation Under Heat Stress by the Chaperonin Hsp60
Martin J, Horwich A, Hartl F. Prevention of Protein Denaturation Under Heat Stress by the Chaperonin Hsp60. Science 1992, 258: 995-998. PMID: 1359644, DOI: 10.1126/science.1359644.Peer-Reviewed Original ResearchConceptsDihydrofolate reductaseShock proteinsMitochondrial heat shock protein 60Native dihydrofolate reductaseHeat shock proteinsVariety of polypeptidesPreexisting proteinsChaperonin Hsp60Hsp60 familyEnvironmental stressHeat shock protein 60Shock protein 60Stress conditionsHeat stressProteinGeneral mechanismPhysiological responsesProtein 60HSP60Cellular structureThermal denaturationProtein denaturationOrganellesDenaturationRefolding