2017
Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice
Thomas EV, Fenton WA, McGrath J, Horwich AL. Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e3139-e3148. PMID: 28348221, PMCID: PMC5393223, DOI: 10.1073/pnas.1701465114.Peer-Reviewed Original ResearchConceptsMotor neuronsChimeric miceSpinal cord motor neuronsCranial nerve motor nucleiDouble fluorescenceMammalian nervous systemMo of ageGray matter oligodendrocytesCytosolic proteinsExtraocular nucleiMotor nucleusSpinal cordNervous systemNeuronsMiceSuperoxide dismutase 1 proteinEight-cell embryosPathogenic proteinsOligodendrocytesDismutase 1 proteinThird chimeraChimeric progenyRecent studiesEGFP chimerasCells
2001
Protein folding taking shape
Horwich A, Fenton W, Rapoport T. Protein folding taking shape. EMBO Reports 2001, 2: 1068-1073. PMID: 11743017, PMCID: PMC1084171, DOI: 10.1093/embo-reports/kve253.Peer-Reviewed Original Research
1999
Chaperone rings in protein folding and degradation
Horwich A, Weber-Ban E, Finley D. Chaperone rings in protein folding and degradation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 11033-11040. PMID: 10500119, PMCID: PMC34237, DOI: 10.1073/pnas.96.20.11033.Peer-Reviewed Original ResearchConceptsSubstrate proteinsNon-native formsProcess of foldingCellular proteinsDegradation chamberProtein foldingStep of recognitionProteolytic complexRing assemblyDivergent fatesConformational changesNative stateProteinChaperoninFoldingCentral cavityCooperative interactionsATPPolypeptideFateChaperonesCompartmentalizationVital roleMotifProtease
1995
From the Cradle to the Grave: Ring Complexes in the Life of a Protein
Weissman J, Sigler P, Horwich A. From the Cradle to the Grave: Ring Complexes in the Life of a Protein. Science 1995, 268: 523-524. PMID: 7725096, DOI: 10.1126/science.7725096.Peer-Reviewed Original Research
1994
Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell
Craig E, Weissman J, Horwich A. Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell. Cell 1994, 78: 365-372. PMID: 7914834, DOI: 10.1016/0092-8674(94)90416-2.Peer-Reviewed Original Research
1993
Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1
Horwich A, Willison K. Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1. Philosophical Transactions Of The Royal Society B Biological Sciences 1993, 339: 313-326. PMID: 8098536, DOI: 10.1098/rstb.1993.0030.Peer-Reviewed Original Research
1992
Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space
Koll H, Guiard B, Rassow J, Ostermann J, Horwich A, Neupert W, Hartl F. Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell 1992, 68: 1163-1175. PMID: 1347713, DOI: 10.1016/0092-8674(92)90086-r.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBiological TransportChaperonin 60ChaperoninsFungal ProteinsHeat-Shock ProteinsL-Lactate DehydrogenaseL-Lactate Dehydrogenase (Cytochrome)MitochondriaMolecular Sequence DataProtein ConformationProtein Sorting SignalsProteinsRecombinant Fusion ProteinsSaccharomyces cerevisiae
1991
Mitochondrial protein import.
Horwich A, Cheng M, West A, Pollock R. Mitochondrial protein import. Current Topics In Microbiology And Immunology 1991, 170: 1-42. PMID: 1760928, DOI: 10.1007/978-3-642-76389-2_1.Peer-Reviewed Original ResearchConceptsMitochondrial protein import pathwayProtein import pathwayPrecise molecular functionConformational alterationsImport pathwayMolecular functionsStep of recognitionMembrane translocationProteolytic cleavageProteinTranslocationDynamic picturePowerful toolGeneticsAlterationsPathwayBiochemistryCleavageCritical features
1990
Protein import into mitochondria and peroxisomes
Horwich A. Protein import into mitochondria and peroxisomes. Current Opinion In Cell Biology 1990, 2: 625-633. PMID: 1979227, DOI: 10.1016/0955-0674(90)90103-l.Peer-Reviewed Original ResearchProtein-catalysed protein folding
Horwich A, Neupert W, Hartl F. Protein-catalysed protein folding. Trends In Biotechnology 1990, 8: 126-131. PMID: 1369433, DOI: 10.1016/0167-7799(90)90153-o.Peer-Reviewed Original Research
1986
Targeting of Nuclear‐Encoded Proteins to the Mitochondrial Matrix: Implications for Human Genetic Defects
ROSENBERG L, FENTON W, HORWICH A, KALOUSEK F, KRAUS J. Targeting of Nuclear‐Encoded Proteins to the Mitochondrial Matrix: Implications for Human Genetic Defects. Annals Of The New York Academy Of Sciences 1986, 488: 99-108. PMID: 3472484, DOI: 10.1111/j.1749-6632.1986.tb54396.x.Peer-Reviewed Original Research