TCP1 complex is a molecular chaperone in tubulin biogenesis
Yaffe M, Farr G, Miklos D, Horwich A, Sternlicht M, Sternlicht H. TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature 1992, 358: 245-248. PMID: 1630491, DOI: 10.1038/358245a0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCycloheximideDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsKineticsMacromolecular SubstancesMicrotubule-Associated ProteinsMolecular WeightNuclear ProteinsProtein BiosynthesisProtein ConformationRabbitsReticulocytesRNA, MessengerT-Complex Genome RegionTubulinUbiquitin-Protein LigasesConceptsReticulocyte lysateTubulin subunitsCytosol of eukaryotesComplex polypeptide 1Protease-sensitive conformationRabbit reticulocyte lysateCytosolic chaperonesTubulin biogenesisMajor cytosolic proteinMolecular chaperonesTCP1 complexK proteinCytosolic proteinsΒ heterodimerBiogenesisPolypeptide 1Β-tubulinProteinSubunitsChaperonesMg-ATPK-complexesMolecular targetsNonhydrolysable analogueTubulin