Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification
Summers J, Smith P, Horwich A. Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. Journal Of Virology 1990, 64: 2819-2824. PMID: 2335817, PMCID: PMC249463, DOI: 10.1128/jvi.64.6.2819-2824.1990.Peer-Reviewed Original ResearchConceptsCccDNA synthesisEnvelope proteinVirus-mediated cell deathHepadnavirus envelope proteinsCircular DNA amplificationViral DNA synthesisWild-type virusWild typeViral envelope proteinsCell deathCircular DNAPrimary duck hepatocytesDNA synthesisProteinDNA amplificationPersistent infectionDuck hepatocytesSynthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells
Horwich A, Furtak K, Pugh J, Summers J. Synthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells. Journal Of Virology 1990, 64: 642-650. PMID: 2153230, PMCID: PMC249155, DOI: 10.1128/jvi.64.2.642-650.1990.Peer-Reviewed Original ResearchConceptsHepatitis B virus genomeDirect repeat 1Duck hepatitis B virus genomesInfectious virusViral DNA synthesisVirus antigen productionCore antigenDNA-containing viral particlesHepatoma cell line Huh7Human hepatoma cell line Huh7Cultured Huh7 cellsDNA synthesisVirus genomeAntigen productionHuh7 cellsEnvelope proteinViral particlesLoss of abilityViral DNA