Featured Publications
Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K. Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology. Nature Communications 2018, 9: 430. PMID: 29382851, PMCID: PMC5789891, DOI: 10.1038/s41467-018-02897-7.Peer-Reviewed Original ResearchConceptsCell proliferationGlycogen synthase kinase-3βC-myc inductionT cell proliferationSynthase kinase-3βNuclear importSer389 phosphorylationGSK3 inhibitorsCell homeostasisT cellsFunction mutationsKinase-3βGenetic targetingDNA damageProtein 5Nuclear translocationT cell homeostasisGSK3β activityT cell activationImportant checkpointGSK3βGimap5Pharmacological inhibitionGIMAP5 deficiencyLymphocyte survivalCharacteristics of Bacteremia in Pediatric Oncology Patients Based on Pathogen Classification as Associated with the Gastrointestinal Mucosa or Skin
Flagg A, Worley S, Foster CB. Characteristics of Bacteremia in Pediatric Oncology Patients Based on Pathogen Classification as Associated with the Gastrointestinal Mucosa or Skin. Infection Control And Hospital Epidemiology 2015, 36: 730-733. PMID: 25773335, DOI: 10.1017/ice.2015.48.Peer-Reviewed Original ResearchConceptsGastrointestinal mucosaCharacteristics of bacteremiaEnteric Gram-negativesBlood stream infectionsPediatric oncology patientsAcute myelogenous leukemiaCentral cathetersOncology patientsOral floraMyelogenous leukemiaSkin organismsBacteremiaPatientsMucosaGram-negativesMucositisCatheterLeukemiaInfectionLymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
Mahat U, Garg B, Yang CY, Mehta H, Hanna R, Rogers HJ, Flagg A, Ivanov AI, Corey SJ. Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia. Blood Advances 2022, 6: 2581-2594. PMID: 34991157, PMCID: PMC9043934, DOI: 10.1182/bloodadvances.2021006398.Peer-Reviewed Original ResearchConceptsLymphocyte cytosolic protein 1Impaired cell motilityDiffuse intracellular localizationUnfolded protein responseCytosolic protein 1Level of genesCell cycle arrestActin regulationG2/M phaseNew genesActin cytoskeletonActin dynamicsCell motilityProtein responseSubcellular fractionationMutant formsF-actinIntracellular localizationWhole-exome sequencingCycle arrestHeLa cellsMissense mutationsHeterozygous missense mutationM phaseLCP1Histiocytic Neoplasms, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Go RS, Jacobsen E, Baiocchi R, Buhtoiarov I, Butler EB, Campbell PK, Coulter DW, Diamond E, Flagg A, Goodman AM, Goyal G, Gratzinger D, Hendrie PC, Higman M, Hogarty MD, Janku F, Karmali R, Morgan D, Raldow AC, Stefanovic A, Tantravahi SK, Walkovich K, Zhang L, Bergman MA, Darlow SD. Histiocytic Neoplasms, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2021, 19: 1277-1303. PMID: 34781268, DOI: 10.6004/jnccn.2021.0053.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHistiocytic neoplasmsNCCN Clinical Practice GuidelinesCommon histiocytic disorderRare hematologic disorderRosai-Dorfman diseaseTreatment of adultsClinical practice guidelinesErdheim-Chester diseaseLangerhans cell histiocytosisNCCN guidelinesSelect patientsSystemic therapyLymph nodesClinical presentationMild diseaseCell histiocytosisHematologic disordersHistiocytic disorderPractice guidelinesOptimal managementPatientsNeoplasmsSoft tissueDiseaseDisordersIncidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury–Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant
Dandoy CE, Kim S, Chen M, Ahn KW, Ardura MI, Brown V, Chhabra S, Diaz MA, Dvorak C, Farhadfar N, Flagg A, Ganguly S, Hale GA, Hashmi SK, Hematti P, Martino R, Nishihori T, Nusrat R, Olsson RF, Rotz SJ, Sung AD, Perales MA, Lindemans CA, Komanduri KV, Riches ML. Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury–Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant. JAMA Network Open 2020, 3: e1918668. PMID: 31913492, PMCID: PMC6991246, DOI: 10.1001/jamanetworkopen.2019.18668.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantAllogeneic hematopoietic stem cell transplantMucosal barrier injury laboratoryMBI-LCBIOutcomes of patientsStem cell transplantBloodstream infectionsCumulative incidenceCell transplantRisk factorsDay 100First allogeneic hematopoietic stem cell transplantMarrow Transplant Research databaseHost disease (GVHD) prophylaxisLansky performance statusTransplant-related mortalityOne-year mortalityTranslocation of bacteriaCord blood graftsCause of deathChronic graftConsecutive pediatricHost diseaseMyeloablative conditioningAdult patientsInfectious diseases in pediatric transplantation: Literature review 2006–2007
Flagg A, Danziger‐Isakov L. Infectious diseases in pediatric transplantation: Literature review 2006–2007. Pediatric Transplantation 2008, 12: 729-736. DOI: 10.1111/j.1399-3046.2008.00985.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsExtranodal marginal zone B cell lymphoma: An unexpected complication in children with Sjögren's syndrome
Collado P, Kelada A, Cámara M, Zeft A, Flagg A. Extranodal marginal zone B cell lymphoma: An unexpected complication in children with Sjögren's syndrome. Reumatología Clínica (English Edition) 2018, 14: 227-229. DOI: 10.1016/j.reumae.2017.01.011.Peer-Reviewed Original ResearchExtranodal marginal zone B-cell lymphomaSjögren's syndromeB-cell lymphomaMarginal zone B-cell lymphomaDiagnosis of SSJuvenile Sjögren's syndromeSalivary glandsPrimary Sjögren's syndromeSystemic autoimmune diseaseInfiltration of lymphocytesRisk of malignancyFine-needle aspirationSicca symptomsNonspecific findingsAutoimmune diseasesUnusual complicationRare conditionNeedle aspirationImmunohistochemical stainingUnexpected complicationsSyndromeExocrine glandsComplicationsLymphomaChildrenNovel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient
Flagg A, Danziger-Isakov L, Foster C, Nasman C, Smedira N, Carl J, Kwon C, Davis S, Boyle G. Novel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient. The Journal Of Heart And Lung Transplantation 2009, 29: 582-584. PMID: 20044274, DOI: 10.1016/j.healun.2009.11.600.Peer-Reviewed Case Reports and Technical NotesConceptsExtracorporeal membrane oxygenationH1N1 influenza virusAcute respiratory distress syndromeCardiothoracic transplant recipientsTransplant recipientsInfluenza virusMembrane oxygenationSevere acute respiratory distress syndromeH1N1 influenza virus infectionPediatric heart transplant recipientsHeart transplant recipientsRespiratory distress syndromeInitiation of treatmentInfluenza virus infectionReal-time reverse transcriptase-polymerase chain reactionCongenital heart diseaseReverse transcriptase-polymerase chain reactionIncidence of infectionTranscriptase-polymerase chain reactionPediatric recipientsDistress syndromePediatric patientsLung diseaseHeart diseaseEarly suspicion
2024
Incidence and risk factors of pain crisis after hematopoietic cell transplantation for sickle cell disease
Krishnamurti L, Liang J, He Z, Deng Y, Nallagatla V, Hamidi R, Flagg A, Shah N. Incidence and risk factors of pain crisis after hematopoietic cell transplantation for sickle cell disease. Blood Advances 2024, 8: 1908-1919. PMID: 38324722, PMCID: PMC11021890, DOI: 10.1182/bloodadvances.2023010749.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseVaso-occlusive episodesPainful crisesCell transplantationPost-HCTGraft failureBefore HCTEvent-free survivalOverall survivalPain syndromePatient agePatient-centered outcomesAlternative donorsIncreased riskCell diseaseRisk factorsNatural historyPatientsLogistic regressionPainTransplantationSurvivalAgeAGVHD
2023
378 Main Reasons for Performing Hematopoietic Cell Transplantation in Patients with Sickle Cell Disease: Evolution over the Last Three Decades
Flagg A, He Z, Deng Y, Hamidi R, Shah N, Krishnamurti L. 378 Main Reasons for Performing Hematopoietic Cell Transplantation in Patients with Sickle Cell Disease: Evolution over the Last Three Decades. Transplantation And Cellular Therapy 2023, 29: s285-s286. DOI: 10.1016/s2666-6367(23)00447-5.Peer-Reviewed Original Research379 The Impact of Current Conditioning Regimen, T Cell Depletion and Graft Versus Host Disease Prophylaxis on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Sickle Cell Disease
Shah N, Flagg A, Hamidi R, Hugo H, Deng Y, Krishnamurti L. 379 The Impact of Current Conditioning Regimen, T Cell Depletion and Graft Versus Host Disease Prophylaxis on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Sickle Cell Disease. Transplantation And Cellular Therapy 2023, 29: s286-s287. DOI: 10.1016/s2666-6367(23)00448-7.Peer-Reviewed Original Research384 Vaso-Occlusive Pain Requiring Hospitalization or Treatment Is Rare Following Successful Hematopoietic Cell Transplantation for Sickle Cell Disease
Krishnamurti L, He Z, Deng Y, Hamidi R, Flagg A, Shah N. 384 Vaso-Occlusive Pain Requiring Hospitalization or Treatment Is Rare Following Successful Hematopoietic Cell Transplantation for Sickle Cell Disease. Transplantation And Cellular Therapy 2023, 29: s291. DOI: 10.1016/s2666-6367(23)00453-0.Peer-Reviewed Original Research390 Endothelial Complications of Hematopoietic Cell Transplantation for Sickle Cell Disease
Flagg A, Hamidi R, He Z, Deng Y, Shah N, Krishnamurti L. 390 Endothelial Complications of Hematopoietic Cell Transplantation for Sickle Cell Disease. Transplantation And Cellular Therapy 2023, 29: s296. DOI: 10.1016/s2666-6367(23)00459-1.Peer-Reviewed Original Research392 Avascular Necrosis Following Hematopoietic Cell Transplantation for Sickle Cell Disease
Hamidi R, He Z, Deng Y, Flagg A, Shah N, Krishnamurti L. 392 Avascular Necrosis Following Hematopoietic Cell Transplantation for Sickle Cell Disease. Transplantation And Cellular Therapy 2023, 29: s297-s298. DOI: 10.1016/s2666-6367(23)00461-x.Peer-Reviewed Original Research
2022
Endothelial Complications of Hematopoietic Cell Transplantation for Sickle Cell Disease
Flagg A, Hamidi R, Deng Y, Shah N, Krishnamurti L, He Z. Endothelial Complications of Hematopoietic Cell Transplantation for Sickle Cell Disease. Blood 2022, 140: 10460-10461. DOI: 10.1182/blood-2022-169107.Peer-Reviewed Original Research434 Adolescent and Young Adult Patients’ Experiences with Hematopoietic Stem Cell Transplant in a Pediatric Hospital Environment
Boyd K, Agli J, Bowers A, Flagg A, Shah N. 434 Adolescent and Young Adult Patients’ Experiences with Hematopoietic Stem Cell Transplant in a Pediatric Hospital Environment. Transplantation And Cellular Therapy 2022, 28: s336-s337. DOI: 10.1016/s2666-6367(22)00594-2.Peer-Reviewed Original Research
2021
Classical Hodgkin Lymphoma of cystic thymus in a patient with infectious mononucleosis: Diagnostic challenges and practical considerations
Bhunia N, Ondrejka S, Flagg A, Buhtoiarov I. Classical Hodgkin Lymphoma of cystic thymus in a patient with infectious mononucleosis: Diagnostic challenges and practical considerations. Pediatric Hematology Oncology Journal 2021, 6: 81-83. DOI: 10.1016/j.phoj.2021.03.002.Peer-Reviewed Case Reports and Technical Notes
2020
Brachial plexus chloroma as a presenting feature of relapse in a child with KMT2A-rearranged acute lymphoblastic leukemia, a case report
Pruitt J, Flagg A, Hanna R, Rotz SJ. Brachial plexus chloroma as a presenting feature of relapse in a child with KMT2A-rearranged acute lymphoblastic leukemia, a case report. Pediatric Hematology And Oncology 2020, 38: 179-183. PMID: 33150840, PMCID: PMC7987733, DOI: 10.1080/08880018.2020.1826071.Peer-Reviewed Case Reports and Technical NotesSevere megaloblastic anemia: Vitamin deficiency and other causes
Socha DS, DeSouza SI, Flagg A, Sekeres M, Rogers HJ. Severe megaloblastic anemia: Vitamin deficiency and other causes. Cleveland Clinic Journal Of Medicine 2020, 87: 153-164. PMID: 32127439, DOI: 10.3949/ccjm.87a.19072.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMegaloblastic anemiaRed blood cell productionVitamin supplementationLaboratory findingsVitamin deficiencyBlood cell productionIntramedullary hemolysisCobalamin deficiencyMacrocytic anemiaCommon causeCase of deficiencySevere casesNeoplastic diseaseCharacteristic morphologicFolate deficiencyUnderlying causeAnemiaCell productionCauseDeficiencyDiscontinuationMedicationsTherapyDiseaseSupplementation
2019
Ovarian Torsion in an Adolescent with Beckwith-Wiedemann Syndrome and Unilateral Tubo-ovarian Hyperplasia
Mahat U, Dermawan JKT, Herman R, Mamoun I, Flagg A. Ovarian Torsion in an Adolescent with Beckwith-Wiedemann Syndrome and Unilateral Tubo-ovarian Hyperplasia. Journal Of Pediatric And Adolescent Gynecology 2019, 32: 446-449. PMID: 30981832, DOI: 10.1016/j.jpag.2019.04.008.Peer-Reviewed Case Reports and Technical NotesConceptsBeckwith-Wiedemann syndromeOvarian hyperplasiaBWS patientsAbdominal painOvarian torsionFallopian tubeOvid MEDLINEEmbryonal tumorsDatabases PubMedExtensive literature searchHyperplasiaOvergrowth syndromePatientsPostmortem specimensLiterature searchPhenotypic presentationOrgan hyperplasiaSyndromeBroad phenotypic presentationBrief literature reviewPrevious reportsLiterature reviewOnline searchPainEMBASE