Featured Publications
Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K. Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology. Nature Communications 2018, 9: 430. PMID: 29382851, PMCID: PMC5789891, DOI: 10.1038/s41467-018-02897-7.Peer-Reviewed Original ResearchConceptsCell proliferationGlycogen synthase kinase-3βC-myc inductionT cell proliferationSynthase kinase-3βNuclear importSer389 phosphorylationGSK3 inhibitorsCell homeostasisT cellsFunction mutationsKinase-3βGenetic targetingDNA damageProtein 5Nuclear translocationT cell homeostasisGSK3β activityT cell activationImportant checkpointGSK3βGimap5Pharmacological inhibitionGIMAP5 deficiencyLymphocyte survivalCharacteristics of Bacteremia in Pediatric Oncology Patients Based on Pathogen Classification as Associated with the Gastrointestinal Mucosa or Skin
Flagg A, Worley S, Foster CB. Characteristics of Bacteremia in Pediatric Oncology Patients Based on Pathogen Classification as Associated with the Gastrointestinal Mucosa or Skin. Infection Control And Hospital Epidemiology 2015, 36: 730-733. PMID: 25773335, DOI: 10.1017/ice.2015.48.Peer-Reviewed Original ResearchConceptsGastrointestinal mucosaCharacteristics of bacteremiaEnteric Gram-negativesBlood stream infectionsPediatric oncology patientsAcute myelogenous leukemiaCentral cathetersOncology patientsOral floraMyelogenous leukemiaSkin organismsBacteremiaPatientsMucosaGram-negativesMucositisCatheterLeukemiaInfectionLymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
Mahat U, Garg B, Yang CY, Mehta H, Hanna R, Rogers HJ, Flagg A, Ivanov AI, Corey SJ. Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia. Blood Advances 2022, 6: 2581-2594. PMID: 34991157, PMCID: PMC9043934, DOI: 10.1182/bloodadvances.2021006398.Peer-Reviewed Original ResearchConceptsLymphocyte cytosolic protein 1Impaired cell motilityDiffuse intracellular localizationUnfolded protein responseCytosolic protein 1Level of genesCell cycle arrestActin regulationG2/M phaseNew genesActin cytoskeletonActin dynamicsCell motilityProtein responseSubcellular fractionationMutant formsF-actinIntracellular localizationWhole-exome sequencingCycle arrestHeLa cellsMissense mutationsHeterozygous missense mutationM phaseLCP1Histiocytic Neoplasms, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Go RS, Jacobsen E, Baiocchi R, Buhtoiarov I, Butler EB, Campbell PK, Coulter DW, Diamond E, Flagg A, Goodman AM, Goyal G, Gratzinger D, Hendrie PC, Higman M, Hogarty MD, Janku F, Karmali R, Morgan D, Raldow AC, Stefanovic A, Tantravahi SK, Walkovich K, Zhang L, Bergman MA, Darlow SD. Histiocytic Neoplasms, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2021, 19: 1277-1303. PMID: 34781268, DOI: 10.6004/jnccn.2021.0053.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHistiocytic neoplasmsNCCN Clinical Practice GuidelinesCommon histiocytic disorderRare hematologic disorderRosai-Dorfman diseaseTreatment of adultsClinical practice guidelinesErdheim-Chester diseaseLangerhans cell histiocytosisNCCN guidelinesSelect patientsSystemic therapyLymph nodesClinical presentationMild diseaseCell histiocytosisHematologic disordersHistiocytic disorderPractice guidelinesOptimal managementPatientsNeoplasmsSoft tissueDiseaseDisordersIncidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury–Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant
Dandoy CE, Kim S, Chen M, Ahn KW, Ardura MI, Brown V, Chhabra S, Diaz MA, Dvorak C, Farhadfar N, Flagg A, Ganguly S, Hale GA, Hashmi SK, Hematti P, Martino R, Nishihori T, Nusrat R, Olsson RF, Rotz SJ, Sung AD, Perales MA, Lindemans CA, Komanduri KV, Riches ML. Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury–Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant. JAMA Network Open 2020, 3: e1918668. PMID: 31913492, PMCID: PMC6991246, DOI: 10.1001/jamanetworkopen.2019.18668.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantAllogeneic hematopoietic stem cell transplantMucosal barrier injury laboratoryMBI-LCBIOutcomes of patientsStem cell transplantBloodstream infectionsCumulative incidenceCell transplantRisk factorsDay 100First allogeneic hematopoietic stem cell transplantMarrow Transplant Research databaseHost disease (GVHD) prophylaxisLansky performance statusTransplant-related mortalityOne-year mortalityTranslocation of bacteriaCord blood graftsCause of deathChronic graftConsecutive pediatricHost diseaseMyeloablative conditioningAdult patientsNovel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient
Flagg A, Danziger-Isakov L, Foster C, Nasman C, Smedira N, Carl J, Kwon C, Davis S, Boyle G. Novel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient. The Journal Of Heart And Lung Transplantation 2009, 29: 582-584. PMID: 20044274, DOI: 10.1016/j.healun.2009.11.600.Peer-Reviewed Case Reports and Technical NotesConceptsExtracorporeal membrane oxygenationH1N1 influenza virusAcute respiratory distress syndromeCardiothoracic transplant recipientsTransplant recipientsInfluenza virusMembrane oxygenationSevere acute respiratory distress syndromeH1N1 influenza virus infectionPediatric heart transplant recipientsHeart transplant recipientsRespiratory distress syndromeInitiation of treatmentInfluenza virus infectionReal-time reverse transcriptase-polymerase chain reactionCongenital heart diseaseReverse transcriptase-polymerase chain reactionIncidence of infectionTranscriptase-polymerase chain reactionPediatric recipientsDistress syndromePediatric patientsLung diseaseHeart diseaseEarly suspicion
2020
Brachial plexus chloroma as a presenting feature of relapse in a child with KMT2A-rearranged acute lymphoblastic leukemia, a case report
Pruitt J, Flagg A, Hanna R, Rotz SJ. Brachial plexus chloroma as a presenting feature of relapse in a child with KMT2A-rearranged acute lymphoblastic leukemia, a case report. Pediatric Hematology And Oncology 2020, 38: 179-183. PMID: 33150840, PMCID: PMC7987733, DOI: 10.1080/08880018.2020.1826071.Peer-Reviewed Case Reports and Technical NotesSevere megaloblastic anemia: Vitamin deficiency and other causes
Socha DS, DeSouza SI, Flagg A, Sekeres M, Rogers HJ. Severe megaloblastic anemia: Vitamin deficiency and other causes. Cleveland Clinic Journal Of Medicine 2020, 87: 153-164. PMID: 32127439, DOI: 10.3949/ccjm.87a.19072.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMegaloblastic anemiaRed blood cell productionVitamin supplementationLaboratory findingsVitamin deficiencyBlood cell productionIntramedullary hemolysisCobalamin deficiencyMacrocytic anemiaCommon causeCase of deficiencySevere casesNeoplastic diseaseCharacteristic morphologicFolate deficiencyUnderlying causeAnemiaCell productionCauseDeficiencyDiscontinuationMedicationsTherapyDiseaseSupplementation
2019
Ovarian Torsion in an Adolescent with Beckwith-Wiedemann Syndrome and Unilateral Tubo-ovarian Hyperplasia
Mahat U, Dermawan JKT, Herman R, Mamoun I, Flagg A. Ovarian Torsion in an Adolescent with Beckwith-Wiedemann Syndrome and Unilateral Tubo-ovarian Hyperplasia. Journal Of Pediatric And Adolescent Gynecology 2019, 32: 446-449. PMID: 30981832, DOI: 10.1016/j.jpag.2019.04.008.Peer-Reviewed Case Reports and Technical NotesConceptsBeckwith-Wiedemann syndromeOvarian hyperplasiaBWS patientsAbdominal painOvarian torsionFallopian tubeOvid MEDLINEEmbryonal tumorsDatabases PubMedExtensive literature searchHyperplasiaOvergrowth syndromePatientsPostmortem specimensLiterature searchPhenotypic presentationOrgan hyperplasiaSyndromeBroad phenotypic presentationBrief literature reviewPrevious reportsLiterature reviewOnline searchPainEMBASE
2017
Mycobacterium genavense‐induced spindle cell pseudotumor in a pediatric hematopoietic stem cell transplant recipient: Case report and review of the literature
Coelho R, Hanna R, Flagg A, Stempak LM, Ondrejka S, Procop GW, Harrington S, Zembillas A, Kusick K, Gonzalez BE. Mycobacterium genavense‐induced spindle cell pseudotumor in a pediatric hematopoietic stem cell transplant recipient: Case report and review of the literature. Transplant Infectious Disease 2017, 19 PMID: 28039955, DOI: 10.1111/tid.12656.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAbdomenAdolescentAlemtuzumabAntibiotic ProphylaxisAntibiotics, AntitubercularAntibodies, Monoclonal, HumanizedBone Marrow TransplantationBronchoalveolar Lavage FluidCyclosporineDiabetes Mellitus, Type 1DiarrheaGenetic Diseases, X-LinkedGraft RejectionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistiocytesHumansImmune System DiseasesImmunosuppressive AgentsLymph NodesMaleMelphalanMycobacterium Infections, NontuberculousMycophenolic AcidNontuberculous MycobacteriaPhotopheresisPolymerase Chain ReactionTransplantation ConditioningVidarabine
2014
Testicular Myeloid Sarcoma: A Rare Manifestation of Acute Myeloid Leukemia in an Infant
Tran CN, Collie AM, Flagg A, Rhee A. Testicular Myeloid Sarcoma: A Rare Manifestation of Acute Myeloid Leukemia in an Infant. Urology 2014, 84: 925-927. PMID: 25260454, DOI: 10.1016/j.urology.2014.07.005.Peer-Reviewed Case Reports and Technical NotesConceptsAcute myeloid leukemiaMyeloid sarcomaMyeloid leukemiaAllogeneic bone marrow transplantationLocal radiation therapyBilateral testicular massesRadical inguinal orchiectomyBone marrow transplantationBone marrow biopsyPainless scrotal swellingBone marrow diseaseInduction chemotherapyInguinal orchiectomyRare manifestationMarrow transplantationMarrow biopsyScrotal swellingMarrow diseaseRadiation therapyTesticular massSurgical pathologySarcomaLeukemiaSeparate entitiesRemissionTransient abnormal myelopoiesis of a newborn not associated with chromosome 21 abnormalities or GATA1 mutations
Nakashima MO, Shetty S, Chicka M, Flagg A, Eng C, Cotta CV. Transient abnormal myelopoiesis of a newborn not associated with chromosome 21 abnormalities or GATA1 mutations. Pediatric Blood & Cancer 2014, 62: 353-355. PMID: 25175265, DOI: 10.1002/pbc.25226.Peer-Reviewed Case Reports and Technical NotesConceptsTransient abnormal myelopoiesisAcute myeloid leukemiaGATA1 mutationsSubsequent acute myeloid leukemiaLeukemic megakaryoblastsSpontaneous remissionAbnormal myelopoiesisMyeloid leukemiaTrisomy 21Megakaryocytic blastsBlood cancersUnique caseGenetic abnormalitiesNewbornsChromosome 21MutationsBlastsRemissionLeukemiaCancerAbnormalities
2013
Synchronous occurrence of nasopharyngeal carcinoma and Hodgkin lymphoma
Stokken J, Manz RM, Flagg A, Gowans L, Anne S. Synchronous occurrence of nasopharyngeal carcinoma and Hodgkin lymphoma. International Journal Of Pediatric Otorhinolaryngology 2013, 78: 154-156. PMID: 24290306, DOI: 10.1016/j.ijporl.2013.10.055.Peer-Reviewed Case Reports and Technical NotesConceptsEpstein-Barr virusHodgkin's lymphomaNasopharyngeal carcinomaLatent Epstein-Barr virus (EBV) infectionEpstein-Barr virus infectionHealthy African American maleAnterior mediastinal massCommon etiologic factorChemo radiationActive diseaseSequential therapyMediastinal massPatient presentingNasopharyngeal massEtiologic factorsVirus infectionEpithelial malignanciesSynchronous occurrenceAfrican American malesCarcinomaLymphomaMalignancyVirusRare eventSimultaneous occurrence