Characteristics of Bacteremia in Pediatric Oncology Patients Based on Pathogen Classification as Associated with the Gastrointestinal Mucosa or Skin
Flagg A, Worley S, Foster CB. Characteristics of Bacteremia in Pediatric Oncology Patients Based on Pathogen Classification as Associated with the Gastrointestinal Mucosa or Skin. Infection Control And Hospital Epidemiology 2015, 36: 730-733. PMID: 25773335, DOI: 10.1017/ice.2015.48.Peer-Reviewed Original ResearchConceptsGastrointestinal mucosaCharacteristics of bacteremiaEnteric Gram-negativesBlood stream infectionsPediatric oncology patientsAcute myelogenous leukemiaCentral cathetersOncology patientsOral floraMyelogenous leukemiaSkin organismsBacteremiaPatientsMucosaGram-negativesMucositisCatheterLeukemiaInfectionLymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
Mahat U, Garg B, Yang CY, Mehta H, Hanna R, Rogers HJ, Flagg A, Ivanov AI, Corey SJ. Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia. Blood Advances 2022, 6: 2581-2594. PMID: 34991157, PMCID: PMC9043934, DOI: 10.1182/bloodadvances.2021006398.Peer-Reviewed Original ResearchConceptsLymphocyte cytosolic protein 1Impaired cell motilityDiffuse intracellular localizationUnfolded protein responseCytosolic protein 1Level of genesCell cycle arrestActin regulationG2/M phaseNew genesActin cytoskeletonActin dynamicsCell motilityProtein responseSubcellular fractionationMutant formsF-actinIntracellular localizationWhole-exome sequencingCycle arrestHeLa cellsMissense mutationsHeterozygous missense mutationM phaseLCP1Novel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient
Flagg A, Danziger-Isakov L, Foster C, Nasman C, Smedira N, Carl J, Kwon C, Davis S, Boyle G. Novel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient. The Journal Of Heart And Lung Transplantation 2009, 29: 582-584. PMID: 20044274, DOI: 10.1016/j.healun.2009.11.600.Peer-Reviewed Case Reports and Technical NotesConceptsExtracorporeal membrane oxygenationH1N1 influenza virusAcute respiratory distress syndromeCardiothoracic transplant recipientsTransplant recipientsInfluenza virusMembrane oxygenationSevere acute respiratory distress syndromeH1N1 influenza virus infectionPediatric heart transplant recipientsHeart transplant recipientsRespiratory distress syndromeInitiation of treatmentInfluenza virus infectionReal-time reverse transcriptase-polymerase chain reactionCongenital heart diseaseReverse transcriptase-polymerase chain reactionIncidence of infectionTranscriptase-polymerase chain reactionPediatric recipientsDistress syndromePediatric patientsLung diseaseHeart diseaseEarly suspicion