2021
A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player
Fesharaki-Zadeh A. A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player. The Neurologist 2021, 27: 249-252. PMID: 34879014, PMCID: PMC9439689, DOI: 10.1097/nrl.0000000000000391.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBiomarkersChronic Traumatic EncephalopathyFootballHumansNeurodegenerative DiseasesConceptsChronic traumatic encephalopathyTraumatic encephalopathyAlzheimer's diseasePrior traumatic brain injuryBehavioral variant frontotemporal dementiaRepetitive head traumaTraumatic brain injuryPrior psychiatric historyPrimary progressive aphasiaVariant frontotemporal dementiaPositron emission tomographyCTE casesClinical presentationHead traumaCase reportClinical historyDefinitive diagnosisClinical algorithmBrain injuryComorbid moodPsychiatric historyCerebrospinal fluidNeuroimaging biomarkersProgressive aphasiaFrontotemporal dementia
2020
Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in
Chiasseu M, Fesharaki-Zadeh A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology Of Disease 2020, 145: 105059. PMID: 32858147, PMCID: PMC7572902, DOI: 10.1016/j.nbd.2020.105059.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryTraumatic brain injuryAlzheimer's diseaseBrain injuryGene-environment interactionsMild closed head injuryMorris water maze testAge-matched wild-type controlsStrong unmet needAccumulation of amyloidAge-matched miceClosed head injuryWater maze testNovel object recognitionPersistent cognitive deficitsProtein gene mutationsIba1 expressionWild-type controlsPhospho-tauClinical manifestationsAD pathologyAD symptomsHead injuryAD pathogenesisRisk factors