2023
Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges
Fesharaki-Zadeh A. Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges. Biomedicines 2023, 11: 3158. PMID: 38137378, PMCID: PMC10740836, DOI: 10.3390/biomedicines11123158.Peer-Reviewed Original ResearchTraumatic encephalopathy syndromeChronic traumatic encephalopathyTraumatic brain injuryRepetitive head impactsEncephalopathy syndromeHeterogeneity of TBIUnique neurodegenerative diseaseEffective clinical treatmentClinical research studiesEarly diagnostic methodsClinical featuresClinical manifestationsTraumatic encephalopathyRange of treatmentsBrain injuryNeuroimaging markerClinical identificationNeurodegenerative conditionsAlzheimer's diseaseClinical treatmentClinical settingClinical researchNeurodegenerative diseasesNeuropathological phenomenaDisease
2020
Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in
Chiasseu M, Fesharaki-Zadeh A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology Of Disease 2020, 145: 105059. PMID: 32858147, PMCID: PMC7572902, DOI: 10.1016/j.nbd.2020.105059.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryTraumatic brain injuryAlzheimer's diseaseBrain injuryGene-environment interactionsMild closed head injuryMorris water maze testAge-matched wild-type controlsStrong unmet needAccumulation of amyloidAge-matched miceClosed head injuryWater maze testNovel object recognitionPersistent cognitive deficitsProtein gene mutationsIba1 expressionWild-type controlsPhospho-tauClinical manifestationsAD pathologyAD symptomsHead injuryAD pathogenesisRisk factors