2018
Limited evidence for adipose‐derived stem cell therapy on the treatment of osteoarthritis
Hurley E, Yasui Y, Gianakos A, Seow D, Shimozono Y, Kerkhoffs G, Kennedy J. Limited evidence for adipose‐derived stem cell therapy on the treatment of osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy 2018, 26: 3499-3507. PMID: 29713784, DOI: 10.1007/s00167-018-4955-x.Peer-Reviewed Original ResearchConceptsStromal vascular fractionPlatelet-rich plasmaTreatment of osteoarthritisClinical outcomesSystematic reviewForm of SVFUse of SVFAdipose-derived stem cell therapyEffects of ADSCsIncidence of swellingFavorable clinical outcomeLevel IV studiesCochrane Library databasesEffects of AdiposeDonor siteStem cell therapySVF injectionComplication rateBiological adjuvantsClinical studiesLevel IVExclusion criteriaLibrary databasesSide effectsAdipose tissue
2015
Platelet-Rich Plasma in the Animal Long-Bone Model: An Analysis of Basic Science Evidence.
Gianakos A, Zambrana L, Savage-Elliott I, Lane J, Kennedy J. Platelet-Rich Plasma in the Animal Long-Bone Model: An Analysis of Basic Science Evidence. Orthopedics 2015, 38: e1079-90. PMID: 26652328, DOI: 10.3928/01477447-20151120-04.Peer-Reviewed Original ResearchConceptsPlatelet-rich plasmaEffect of PRPPercent of studiesLong bone modelsUse of PRPPlatelet concentrationBasic science evidencePubMed/MEDLINESignificant increaseEarly bone healingAdditional treatment variablesPeer-reviewed journalsCase seriesLong bone healingPRP groupEmbase databasesBlood productsClinical studiesHistomorphometric assessmentBone pathologyBone areaPlatelet productsBone healingBeneficial effectsVivo evidence