2016
The Efficacy of Bisphosphonates with Core Decompression and Mesenchymal Stem Cells Compared with Bisphosphonates Alone in the Treatment of Osteonecrosis of the Hip: A Retrospective Study
Gianakos A, Moya-Angeler J, Duggal S, Zambrana L, Fields K, Mintz D, Cornell C, Lane J. The Efficacy of Bisphosphonates with Core Decompression and Mesenchymal Stem Cells Compared with Bisphosphonates Alone in the Treatment of Osteonecrosis of the Hip: A Retrospective Study. HSS Journal ® 2016, 12: 137-144. PMID: 27385942, PMCID: PMC4916091, DOI: 10.1007/s11420-016-9487-7.Peer-Reviewed Original ResearchModified Harris Hip ScoreVisual analogue scoreTotal hip arthroplastyBisphosphonate therapyCore decompressionMesenchymal stem cellsFunctional outcomeTreatment groupsHip replacementFemoral headEfficacy of bisphosphonatesFicat stage IRadiologic outcome measuresHarris hip scoreYear of diagnosisTreatment of osteonecrosisFuture prospective studiesEarly-stage ONFHInclusion/exclusion criteriaStem cellsJoint preserving proceduresTotal hip replacementProgression of collapseFicat stageInstitution's registryTreatment of Pre-Collapse Stages of Osteonecrosis of the Femoral Head: a Systematic Review of Randomized Control Trials
Villa J, Husain S, van der List J, Gianakos A, Lane J. Treatment of Pre-Collapse Stages of Osteonecrosis of the Femoral Head: a Systematic Review of Randomized Control Trials. HSS Journal ® 2016, 12: 261-271. PMID: 27703421, PMCID: PMC5026659, DOI: 10.1007/s11420-016-9505-9.Peer-Reviewed Original ResearchRandomized clinical trialsFemoral head collapseBone marrow mesenchymal cellsCore decompressionPre-collapse ONFHHead collapseLower riskFemoral headSystematic reviewLow-level evidence studiesMore RCTsQuestions/PurposesThe purposeNew combination therapiesMeta-Analyses (PRISMA) guidelinesRandomized control trialStandardized outcome measuresPreferred Reporting ItemsPre-collapse stageMethodsUsing PubMedRadiologic outcomesBisphosphonate treatmentClinical evidenceMarrow mesenchymal cellsCombination therapyFunctional outcome
2015
Current concepts on osteonecrosis of the femoral head
Moya-Angeler J, Gianakos A, Villa J, Ni A, Lane J. Current concepts on osteonecrosis of the femoral head. World Journal Of Orthopedics 2015, 6: 590-601. PMID: 26396935, PMCID: PMC4573503, DOI: 10.5312/wjo.v6.i8.590.Peer-Reviewed Original ResearchMagnetic resonance imagingFemoral headCore decompressionFrog-leg lateral radiographsNatural historyFirst radiographic changeTrue natural historyLevel 1 evidenceOptimal treatment protocolTotal hip arthroplastyJoint preserving proceduresPre-collapse stageOsteonecrosis diagnosisPlain anteroposteriorSurgical treatmentAvascular necrosisPlain radiographsSclerotic changesTreatment optionsMinimal symptomsRadiographic changesTreatment modalitiesRisk factorsPharmacologic agentsSymptomatic stage