2024
MAP kinase phosphatase-1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution
Fortier S, Walker N, Penke L, Baas J, Shen Q, Speth J, Huang S, Zemans R, Bennett A, Peters-Golden M. MAP kinase phosphatase-1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution. Journal Of Clinical Investigation 2024, 134: e172826. PMID: 38512415, PMCID: PMC11093610, DOI: 10.1172/jci172826.Peer-Reviewed Original ResearchConceptsMAPK phosphatase 1Fibrosis resolutionPulmonary fibrosisSpontaneous resolutionLung fibrosisBleomycin-induced lung fibrosisLung fibroblastsProgressive pulmonary fibrosisFibroblast-specific deletionExperimental lung fibrosisCells to apoptosisLung injuryRegulation of MAPK activityApoptosis-resistant myofibroblastsTransgenic miceResident fibroblastsTissue injuryFibrosisLung myofibroblastsLoss-of-function studiesGain- and loss-of-function studiesLungVX-702MyofibroblastsMAPK activation
2010
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching
Jeanneteau F, Deinhardt K, Miyoshi G, Bennett AM, Chao MV. The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nature Neuroscience 2010, 13: 1373-1379. PMID: 20935641, PMCID: PMC2971689, DOI: 10.1038/nn.2655.Peer-Reviewed Original ResearchAnimalsAxonsBrain-Derived Neurotrophic FactorCells, CulturedCerebral CortexDual Specificity Phosphatase 1ElectroporationEmbryo, MammalianFemaleGene Expression Regulation, EnzymologicGreen Fluorescent ProteinsHomeodomain ProteinsJNK Mitogen-Activated Protein KinasesMiceMice, TransgenicMicrotubulesNeuronsPregnancyRatsRats, Sprague-DawleyTransfection