2020
Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Savic LJ, Doemel LA, Schobert IT, Montgomery RR, Joshi N, Walsh JJ, Santana J, Pekurovsky V, Zhang X, Lin M, Adam L, Boustani A, Duncan J, Leng L, Bucala RJ, Goldberg SN, Hyder F, Coman D, Chapiro J. Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy? Radiology 2020, 296: 575-583. PMID: 32633675, PMCID: PMC7434651, DOI: 10.1148/radiol.2020200373.Peer-Reviewed Original ResearchConceptsImmuno-oncologic therapiesConventional transarterial chemoembolizationTransarterial chemoembolizationIntratumoral immune cell infiltrationMR spectroscopyRabbit liver tumor modelPrussian blue iron stainingAntigen-presenting immune cellsIntra-arterial infusionImmune cell infiltrationNew Zealand white rabbitsLiver tumor modelImmune cell exclusionLiver cancer modelContrast material administrationT2-weighted MRIZealand white rabbitsT2-weighted imagingResistance mechanismsImmunosuppressive tumorHLA-DRCell infiltrationImmune cellsImmunohistochemistry stainingRing enhancement
2018
Molecular imaging of prostate cancer
Boustani AM, Pucar D, Saperstein L. Molecular imaging of prostate cancer. British Journal Of Radiology 2018, 91: 20170736. PMID: 29243485, PMCID: PMC5966010, DOI: 10.1259/bjr.20170736.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyEarly Detection of CancerHumansMaleMolecular ImagingNeoplasm StagingProstatic NeoplasmsRisk AssessmentConceptsProstate cancerNational Comprehensive Cancer Network guidelinesMetastatic diseaseMolecular imagingCommon malignancyNetwork guidelinesEffective treatmentMolecular imaging techniquesCancerMetabolic intermediaryTreatmentImaging techniquesRelevant radiotracersImagingTimely detectionAccurate imagingChemotherapySurgeryRecurrenceMalignancyDiseaseReceptors