Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia
Amadi B, Besa E, Zyambo K, Kaonga P, Louis-Auguste J, Chandwe K, Tarr PI, Denno DM, Nataro JP, Faubion W, Sailer A, Yeruva S, Brantner T, Murray J, Prendergast AJ, Turner JR, Kelly P. Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia. EBioMedicine 2017, 22: 191-199. PMID: 28750860, PMCID: PMC5552244, DOI: 10.1016/j.ebiom.2017.07.017.Peer-Reviewed Original ResearchConceptsSevere acute malnutritionHealthy childrenVillus heightIntestinal barrier failureImpaired barrier functionBacterial translocationImmune dysregulationIntestinal damageIntestinal secretionPersistent diarrheaAcute malnutritionAutoantibody generationHistological lesionsMalnourished childrenTranslocation markersCrypt depthNormal rangeHealthy adultsIgG concentrationsClaudin-4Adult controlsAnalysis of markersBarrier functionMalnutritionEpithelial surface