2011
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner
King IL, Fortier A, Tighe M, Dibble J, Watts GF, Veerapen N, Haberman AM, Besra GS, Mohrs M, Brenner MB, Leadbetter EA. Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nature Immunology 2011, 13: 44-50. PMID: 22120118, PMCID: PMC3833037, DOI: 10.1038/ni.2172.Peer-Reviewed Original ResearchActivated germinal centre B cells undergo directed migration.
O'Connor MJ, Hauser AE, Haberman AM, Kleinstein SH. Activated germinal centre B cells undergo directed migration. International Journal Of Data Mining And Bioinformatics 2011, 5: 321-31. PMID: 21805826, PMCID: PMC4343311, DOI: 10.1504/ijdmb.2011.040387.Peer-Reviewed Original Research
2002
Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced
Dal Porto JM, Haberman AM, Kelsoe G, Shlomchik MJ. Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced. Journal Of Experimental Medicine 2002, 195: 1215-1221. PMID: 11994427, PMCID: PMC2193705, DOI: 10.1084/jem.20011550.Peer-Reviewed Original ResearchConceptsAntibody-forming cellsMemory B cellsImmune responseB cellsB cell antigen receptorT cell-dependent immune responsesCell-dependent immune responsesLow-affinity B cellsH chain transgenic miceMemory B cell populationsHigh affinity competitionSecondary immune responseSpecific immune responseAntigen-specific cellsGerminal center responseSuch B cellsB cell populationsH chain transgeneLate primary responseGerminal centersTransgenic miceCenter responseCell antigen receptorAntigen receptorPrimary response
2000
Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells
Hannum L, Haberman A, Anderson S, Shlomchik M. Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells. Journal Of Experimental Medicine 2000, 192: 931-942. PMID: 11015435, PMCID: PMC2193308, DOI: 10.1084/jem.192.7.931.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodiesAntigen-Antibody ComplexB-LymphocytesDendritic Cells, FollicularFemaleGenes, ImmunoglobulinGerminal CenterHaptensImmunoglobulin lambda-ChainsImmunoglobulin Variable RegionMaleMiceMice, Inbred BALB CMice, TransgenicMolecular Sequence DataNitrophenolsPhenylacetatesReceptors, Antigen, B-CellA B-cell receptor-specific selection step governs immature to mature B cell differentiation
Levine M, Haberman A, Sant'Angelo D, Hannum L, Cancro M, Janeway C, Shlomchik M. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 2743-2748. PMID: 10688906, PMCID: PMC16000, DOI: 10.1073/pnas.050552997.Peer-Reviewed Original ResearchConceptsImmature B cellsMature B cellsB cell receptor repertoirePositive selection eventsB cell differentiationReceptor repertoireSelection eventsCell differentiationB cellsChain pairsCell receptor repertoirePeripheral B cellsReceptor specificityTime cellsMajor forceCell fractionCellsAdaptive immune responsesRepertoireConventional B cellsAvailable repertoireSelection stepImmune responseB cell fractionsSignificant skewing