2022
Spectrum of qualitative and quantitative imaging of pilomyxoid, intermediate pilomyxoid and pilocytic astrocytomas in relation to their genetic alterations
Fadel SA, von Reppert M, Kazarian E, Omay EZE, Marks A, Linder N, Hoffmann KT, Darbinyan A, Huttner A, Aboian MS. Spectrum of qualitative and quantitative imaging of pilomyxoid, intermediate pilomyxoid and pilocytic astrocytomas in relation to their genetic alterations. Neuroradiology 2022, 65: 195-205. PMID: 35984480, DOI: 10.1007/s00234-022-03027-3.Peer-Reviewed Original ResearchConceptsPilocytic astrocytomaImaging characteristicsADC valuesAggressive imaging characteristicsSuprasellar pilocytic astrocytomaRecurrence/progressionPediatric brain tumorsFrontal white matterWhole-exome sequencingPilomyxoid astrocytomaIntraventricular extensionSuprasellar regionThird ventriclePosterior fossaAtypical locationBrain tumorsWhite matterGrade 1TumorsAstrocytomasDriver mutationsExome sequencingGenetic alterationsPatientsHippocampus
2021
ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody
Rattray Z, Deng G, Zhang S, Shirali A, May CK, Chen X, Cuffari BJ, Liu J, Zou P, Rattray N, Johnson CH, Dubljevic V, Campbell JA, Huttner A, Baehring JM, Zhou J, Hansen JE. ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody. JCI Insight 2021, 6: e145875. PMID: 34128837, PMCID: PMC8410084, DOI: 10.1172/jci.insight.145875.Peer-Reviewed Original ResearchConceptsBlood-brain barrierAnti-DNA autoantibodiesBrain tumorsBreast cancer brain metastasesBlood-brain barrier transportBrain tumor immunotherapyCancer brain metastasesBrain endothelial cellsEndothelial cell penetrationCNS lupusNeurotoxic autoantibodiesBrain metastasesTumor immunotherapyBarrier transportAntibody-based approachesCNS penetrationAutoantibodiesEfficacy studiesOrthotopic glioblastomaEndothelial cellsTumorsCancer cellsNucleoside fluxesActionable mechanismsKey transporters
2020
Extent of Surgical Resection of Epidermoid Tumors Affects Risk of Recurrence: Results of the Largest Meta-analysis of 691 Patients
Shear B, Jin L, Zhang Y, David W, Fomchenko E, Erson-Omay E, Huttner A, Fulbright R, Moliterno J. Extent of Surgical Resection of Epidermoid Tumors Affects Risk of Recurrence: Results of the Largest Meta-analysis of 691 Patients. Journal Of Neurological Surgery Part B Skull Base 2020, 81: s1-s272. DOI: 10.1055/s-0040-1702325.Peer-Reviewed Original Research
2019
Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report
Roque A, Kimbrough T, Traner C, Baehring JM, Huttner A, Adams J, Canosa S, Sklar J, Madri JA. Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report. Journal Of Medical Case Reports 2019, 13: 389. PMID: 31874650, PMCID: PMC6930684, DOI: 10.1186/s13256-019-2317-z.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCarney ComplexChemoradiotherapyCyclic AMP-Dependent Protein Kinase RIalpha SubunitDopamine AgentsExome SequencingFemaleGene Expression Regulation, NeoplasticGenes, Tumor SuppressorGerm-Line MutationHeart NeoplasmsHumansIntracranial HemorrhagesMemantineMiddle AgedMyxomaTreatment OutcomeConceptsAtrial myxomaSporadic tumorsExtra-cardiac complicationsMetastatic cardiac myxomaMajority of tumorsDissemination of tumorsIntracranial hemorrhagic lesionsWhole-exome sequencingAutosomal dominant conditionConclusionsOur patientsSporadic myxomasInvasive tumor cellsParenchymal metastasesCardiac myxomaCase reportClinical behaviorHemorrhagic lesionsAneurysm formationBenign neoplasmsMyxomaSporadic lesionsVascular wallCarney complexTumorsGermline mutations
2018
Leptomeningeal dissemination from low-grade neuroepithelial CNS tumors in adults: a 15-year experience (P6.159)
Karschnia P, Barbiero F, Schwaiblmair M, Piepmeier J, Huttner A, Becker K, Fulbright R, Baehring J. Leptomeningeal dissemination from low-grade neuroepithelial CNS tumors in adults: a 15-year experience (P6.159). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p6.159.Peer-Reviewed Original Research
2017
Leiomyosarcoma of the infratemporal fossa with perineurial spread along the right mandibular nerve: a case report
Barbiero FJ, Huttner AJ, Judson BL, Baehring JM. Leiomyosarcoma of the infratemporal fossa with perineurial spread along the right mandibular nerve: a case report. CNS Oncology 2017, 06: 281-285. PMID: 28990793, PMCID: PMC6004886, DOI: 10.2217/cns-2017-0004.Peer-Reviewed Original ResearchConceptsMandibular nerveRight mandibular nerveRight cavernous sinusSmooth muscle differentiationNerve biopsyCase reportMass lesionNeck cancerCavernous sinusMalignant tumorsGI tractInfratemporal fossaMedical literatureLeiomyosarcomaSkin appendagesSimilar casesNerveTumorsMuscle differentiationPeculiar patternDiplopiaHeadacheBiopsyPatientsMyometrium
2016
Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors
Saucier-Sawyer JK, Seo YE, Gaudin A, Quijano E, Song E, Sawyer AJ, Deng Y, Huttner A, Saltzman WM. Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors. Journal Of Controlled Release 2016, 232: 103-112. PMID: 27063424, PMCID: PMC4893898, DOI: 10.1016/j.jconrel.2016.04.006.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryBlood-brain barrierBrain-penetrating nanoparticlesIntracranial tumorsBrain tumorsGlioblastoma multiformeHealthy brainMain tumor massFatal brain tumorPresence of tumorBrain tumor treatmentLocal recurrenceInfusion sitePeritumoral tissuesTumor massCED infusionIndividual tumorsTumorsNecrotic regionsTumor treatmentLocal administrationHeterogeneous distribution patternAdministrationBrainCell targeting
2014
Thoracic Epidural Teratoma: Case Report and Review of the Literature
Quon JL, Grant RA, Huttner AJ, Duncan CC. Thoracic Epidural Teratoma: Case Report and Review of the Literature. Clinical Pathology 2014, 7: cpath.s14723. PMID: 24940089, PMCID: PMC4055415, DOI: 10.4137/cpath.s14723.Peer-Reviewed Original ResearchSpinal teratomaClinical presentationSevere spinal cord compressionDiagnosis of teratomaSpinal cord compressionGross total resectionSpinal cord tumorsHeterogeneous contrast enhancementSignificant neurologic compromiseClinician's differentialMarked spasticityAmbulatory functionCord compressionCord tumorsTotal resectionNeurologic compromiseEpidural tumorCystic massRare entityCase reportRare subsetMotor milestonesTumorsTeratomaPathophysiology
2012
Overview of Primary Brain Tumors Pathologic Classification, Epidemiology, Molecular Biology, and Prognostic Markers
Huttner A. Overview of Primary Brain Tumors Pathologic Classification, Epidemiology, Molecular Biology, and Prognostic Markers. Hematology/Oncology Clinics Of North America 2012, 26: 715-732. PMID: 22794280, DOI: 10.1016/j.hoc.2012.05.004.Peer-Reviewed Original ResearchConceptsBrain tumor patientsBrain tumor tissueMolecular diagnostic testingMolecular diagnostic testsMultidisciplinary managementPrimary brainNeuroepithelial tumorsHistopathological assessmentPathologic classificationPrognostic markerTumor patientsClinical significanceBrain tumorsClinical practiceTumor tissueDiagnostic testingDiagnostic testsMolecular testsTumorsTumor classificationEpigenetic changesPatientsOverview of classificationPrognosisNeuropathology
2010
Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1
Huttner AJ, Kieran MW, Yao X, Cruz L, Ladner J, Quayle K, Goumnerova LC, Irons MB, Ullrich NJ. Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1. Pediatric Blood & Cancer 2010, 54: 890-896. PMID: 20310005, DOI: 10.1002/pbc.22462.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsChildChild, PreschoolDNA Modification MethylasesDNA Repair EnzymesErbB ReceptorsGene DosageGlioblastomaHumansImmunohistochemistryIn Situ HybridizationInfantKaplan-Meier EstimateMaleNeurofibromatosis 1PTEN PhosphohydrolaseRetrospective StudiesTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsNeurofibromatosis type 1Malignant tumorsType 1Median overall survivalLow-grade tumorsPeripheral nervous systemEpidermal growth factor receptor copy numberNon-NF1 patientsAdditional molecular studiesClinicopathologic studyOverall prognosisOverall survivalRetrospective reviewVascular proliferationPathologic indicatorsPatientsNervous systemTumors differsSame time periodGlioblastomaSmall sample sizeTumorsMethylguanine-DNA methyltransferase (MGMT) geneSurvivalChildren
2009
Primary, non-exophytic, optic nerve germ cell tumors
DiLuna ML, Two AM, Levy GH, Patel T, Huttner AJ, Duncan CC, Piepmeier JM. Primary, non-exophytic, optic nerve germ cell tumors. Journal Of Neuro-Oncology 2009, 95: 437-443. PMID: 19554263, DOI: 10.1007/s11060-009-9941-1.Peer-Reviewed Original ResearchConceptsGerm cell tumorsOptic chiasmatic gliomasMalignant mixed germ cell tumorMixed germ cell tumorOptic chiasmCell tumorsOptic chiasm tumorAdrenal axis dysfunctionSub-frontal approachChiasm gliomaChiasmatic gliomasAxis dysfunctionBiopsy confirmationProgressive symptomsVisual lossCase seriesFirst patientTreatment regimensPterional craniotomyDiabetes insipidusTissue diagnosisTissue biopsiesTumorsPatientsChiasm