2021
Exome sequencing identifies SLIT2 variants in primary CNS lymphoma
Kaulen LD, Erson‐Omay E, Henegariu O, Karschnia P, Huttner A, Günel M, Baehring JM. Exome sequencing identifies SLIT2 variants in primary CNS lymphoma. British Journal Of Haematology 2021, 193: 375-379. PMID: 33481259, DOI: 10.1111/bjh.17319.Peer-Reviewed Original ResearchConceptsPrimary central nervous system lymphomaShorter progression-free survivalCentral nervous system lymphomaRole of SLIT2Primary CNS lymphomaProgression-free survivalLarger validation cohortNervous system lymphomaShorter overall survivalPossible prognostic implicationsWarrants further investigationCNS lymphomaTumor DNA samplesOverall survivalPCNSL patientsSystem lymphomaPrognostic implicationsValidation cohortPCNSL pathogenesisLymphoid malignanciesFunction variantsTumor suppressor geneExome sequencingLuciferase assayLymphoma
2017
RARE-05. PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA IN IMMUNOCOMPROMISED HOSTS – A SINGLE INSTITUTION RETROSPECTIVE STUDY (2002-2017)
Kaulen L, Galluzzo D, Hui P, Huttner A, Fulbright R, Baehring J. RARE-05. PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA IN IMMUNOCOMPROMISED HOSTS – A SINGLE INSTITUTION RETROSPECTIVE STUDY (2002-2017). Neuro-Oncology 2017, 19: vi212-vi212. PMCID: PMC5692004, DOI: 10.1093/neuonc/nox168.858.Peer-Reviewed Original ResearchPrimary central nervous system lymphomaImmunocompromised hostPrognostic factorsSystem lymphomaPeripheral enhancementAutoimmune disordersImaging featuresCentral nervous system post-transplant lymphoproliferative disorderLong-term immunosuppressive treatmentPost-transplant lymphoproliferative disorderHuman immunodeficiency virus (HIV) infectionSingle-institution retrospective studyCentral nervous system lymphomaKaplan-Meier survival analysisDiffuse large B-cell lymphomaYale-New Haven HospitalLarge B-cell lymphomaOverall median survivalImmunodeficiency virus infectionPredictors of survivalSeverity of comorbiditiesNegative prognostic factorNervous system lymphomaDistinct clinical featuresShorter overall survival