ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody
Rattray Z, Deng G, Zhang S, Shirali A, May CK, Chen X, Cuffari BJ, Liu J, Zou P, Rattray N, Johnson CH, Dubljevic V, Campbell JA, Huttner A, Baehring JM, Zhou J, Hansen JE. ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody. JCI Insight 2021, 6: e145875. PMID: 34128837, PMCID: PMC8410084, DOI: 10.1172/jci.insight.145875.Peer-Reviewed Original ResearchConceptsBlood-brain barrierAnti-DNA autoantibodiesBrain tumorsBreast cancer brain metastasesBlood-brain barrier transportBrain tumor immunotherapyCancer brain metastasesBrain endothelial cellsEndothelial cell penetrationCNS lupusNeurotoxic autoantibodiesBrain metastasesTumor immunotherapyBarrier transportAntibody-based approachesCNS penetrationAutoantibodiesEfficacy studiesOrthotopic glioblastomaEndothelial cellsTumorsCancer cellsNucleoside fluxesActionable mechanismsKey transportersNocardia thailandica Brain Abscess in an Immunocompromised Patient
Effendi M, Tirmizi S, McManus D, Huttner AJ, Peaper DR, Topal JE. Nocardia thailandica Brain Abscess in an Immunocompromised Patient. Case Reports In Infectious Diseases 2021, 2021: 6620049. PMID: 34234968, PMCID: PMC8216818, DOI: 10.1155/2021/6620049.Peer-Reviewed Original ResearchSuccessful treatmentCentral nervous system infectionRadiographic treatment successInitiation of therapyNervous system infectionCeftriaxone 2Ceftriaxone monotherapyRadiological improvementBrain abscessesSystem infectionMedical therapyTreatment successCNS penetrationPatientsMedical literatureInfectionBrainTherapyTreatmentMonthsMonotherapyAbscessCeftriaxoneCraniotomy