Ania Jastreboff, MD, PhD
Cards
Professional Highlights
About
Research
Clinical Care
Professional Highlights
About
Research
Clinical Care
Professional Highlights
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Titles
Associate Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Appointments
Titles
Associate Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Appointments
Titles
Associate Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Appointments
Publications Overview
- 99 Publications
- 5,741 Citations
- 48 Yale Co-Authors
Y-Weight: Yale Obesity Research Center
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
2012
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
2012
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
2012
Clinical Specialties
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Titles
Associate Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Appointments
Titles
Associate Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Appointments
Titles
Associate Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Appointments
Publications Overview
- 99 Publications
- 5,741 Citations
- 48 Yale Co-Authors
Y-Weight: Yale Obesity Research Center
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
2012
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
2012
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
2012
Clinical Specialties
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 7 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
About
Titles
Associate Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight); Co-Director, Yale Center for Weight Management; Medical Director, Yale Stress Center
Biography
Ania M. Jastreboff, MD, PhD is an Associate Professor in Medicine and Pediatrics at Yale School of Medicine. She serves as the director of the Yale Obesity Research Center (Y-Weight) and the co-director of the Yale Center for Weight Management. She is trained in both adult endocrinology and pediatric endocrinology, is an obesity medicine physician-scientist, and an international leader in research and clinical application of anti-obesity pharmacotherapeutics. Her work has included working to develop Obesity Clinical Practice Guidelines (AACE/ACE 2016), serving on the Board of Directors for the American Board of Obesity Medicine, educating the next generation of Obesity Medicine physicians by teaching at national and international obesity treatment courses, and conducting cutting-edge clinical-translational obesity research. Her research includes large, multi-center clinical outcomes trials using novel anti-obesity pharmacotherapeutics and studies examining the neurobiology underlying obesity and mechanisms of anti-obesity medications (supported by the NIH/NIDDK). Recently, she has served as lead author for trials investigating potential novel nutrient-stimulated hormone-based therapies for obesity including dual hormone receptor agonist tirzepatide (NEJM) a novel GIP/GLP-1 receptor agonist (Jastreboff, et al., NEJM, 2022) and triple hormone receptor agonist retatrutide (NEJM) a novel GIP/GLP-1/Glucagon receptor agonist (Jastreboff, et al., NEJM, 2023). Dr. Jastreboff thoughtfully advocates for compassionate care for patients with obesity and was recently interviewed Oprah.
Videos of Dr. Jastreboff and colleagues from the NEJM about:
- What causes obesity: https://www.nejm.org/doi/full/...
- Supporting patients with obesity: https://www.nejm.org/doi/full/...
- Medications and surgery for obesity treatment: https://www.nejm.org/doi/full/...
Yale video with Dr. Jastreboff about anti-obesity medications and the biology of obesity.
Podcast (Yale Talk) with the president of Yale University, Dr. Peter Salovey, speaking with Dr. Jastreboff.
Clinically, Dr. Jastreboff specializes in sophisticated use of anti-obesity medication combinations to help patients reach their weight and health goals.
Appointments
Endocrinology
Associate Professor on TermPrimaryGeneral Pediatrics
Associate Professor on TermSecondary
Other Departments & Organizations
- Center for Weight Management
- Diabetes Center
- Diabetes Program
- Diabetes Research Center
- Endocrinology
- General Pediatrics
- Internal Medicine
- Obesity Research Working Group
- Pediatric Weight Solutions Program
- Status of Women in Medicine Committee (SWIM)
- Yale Medicine
- Yale Obesity Research Center (Y-Weight)
- Yale Stress Center
Education & Training
- Student - Yale Advanced Emerging Leaders
- Yale University (2023)
- Yale Public Voices Fellowship
- Yale University (2022)
- Clinical Scholar
- Yale University School of Medicine (2013)
- YCCI Clinical Research Scholar
- Yale School of Medicine (2013)
- PhD
- Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
- Neuromanaging in Psychiatry
- Yale School of Medicine (2011)
- Postdoctoral Fellowship
- Yale School of Medicine (2011)
- Postdoctoral Fellowship
- Yale School of Medicine (2011)
- Food Policy and Science
- Yale University (2010)
- Learning to Mentor the next generation of scientists
- Yale School of Medicine (2009)
- Nutrition and Chronic Disease
- Yale University (2009)
- Chief Resident
- University of Maryland (2006)
- Residency
- University of Maryland School of Medicine (2006)
- Intern
- University of Maryland (2003)
- MD
- University of Maryland at Baltimore (2002)
- BA
- Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Research
Overview
obesity and cancer; anti-obesity pharmacotherapy; cancer prevention and risk reduction
Medical Research Interests
Public Health Interests
ORCID
0000-0003-1446-0991Y-Weight: Yale Obesity Research Center
Investigating novel pharmacological therapeutics for obesity treatment and probing the mechanisms of obesity in translational physiology studies
View Lab Website
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Rajita Sinha, PhD
Wendy Silverman, PhD, ABPP
Michelle Van Name, MD
Alissa Chen, MD, MPH
Carlos Grilo, PhD
Christopher Maulion, MD
Publications
2024
Eligibility for Anti-Obesity Medications through Medicare for Older Adults with Overweight or Obesity
Chetty A, Khunte M, Chen A, Jastreboff A, Krumholz H, Lu Y. Eligibility for Anti-Obesity Medications through Medicare for Older Adults with Overweight or Obesity. American Heart Journal 2024, 278: 8. DOI: 10.1016/j.ahj.2024.09.022.Peer-Reviewed Original ResearchConceptsAnti-obesity medicationsOlder adultsType 2 diabetesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyCardiovascular diseaseNutrition Examination SurveyOlder ageMale sexExamination SurveyMinority race/ethnicitySociodemographic statusPopulation of beneficiariesMedicare beneficiariesPost-MarchLow-incomeMedicare Part D.Medicare coverageMedicareStudy sampleWhite racePre-marchEligibility ratesObesityPooled dataTirzepatide for Obesity Treatment and Diabetes Prevention
Jastreboff A, le Roux C, Stefanski A, Aronne L, Halpern B, Wharton S, Wilding J, Perreault L, Zhang S, Battula R, Bunck M, Ahmad N, Jouravskaya I. Tirzepatide for Obesity Treatment and Diabetes Prevention. New England Journal Of Medicine 2024 PMID: 39536238, DOI: 10.1056/nejmoa2410819.Peer-Reviewed Original ResearchAltmetricConceptsType 2 diabetesProgression to type 2 diabetesDose escalation periodRisk of progression to type 2 diabetesBody weightDoses of tirzepatideBaseline to weekOnce-weekly dosingOff-treatment periodSustained weight reductionYear of treatmentDiagnosis of type 2 diabetesAssigned doseDouble-blindPlacebo groupAdverse eventsTirzepatideTirzepatide groupsPlaceboCausal precursorsSafety signalsObesity treatmentSustained reductionDelay progression to type 2 diabetesObesitySurvodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™‐1 and ‐2)
Wharton S, le Roux C, Kosiborod M, Platz E, Brueckmann M, Jastreboff A, Hussain S, Pedersen S, Borowska L, Unseld A, Kloer I, Kaplan L, committees and investigators T. Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™‐1 and ‐2). Obesity 2024 PMID: 39495965, DOI: 10.1002/oby.24184.Peer-Reviewed Original ResearchAltmetricConceptsTreatment of obesityBaseline BMIRandomized phase 3 clinical trialOnce-weekly subcutaneous injectionsPhase 3 clinical trialsBaseline to weekDouble-blind trialObesity-related complicationsBody weight reductionAbsence of T2DSystolic blood pressureLiver fat contentType 2 diabetesMagnetic resonance imagingMeasures of glycemiaSecondary endpointsDosing flexibilityProportion of participantsLifestyle modificationInvestigated glucagonSubcutaneous injectionBlood pressureBody compositionResonance imagingObesityEligibility for Anti-Obesity Medications Among Medicare Beneficiaries with Overweight or Obesity
Chetty A, Khunte M, Chen A, Jastreboff A, Krumholz H, Lu Y. Eligibility for Anti-Obesity Medications Among Medicare Beneficiaries with Overweight or Obesity. Journal Of General Internal Medicine 2024, 1-3. PMID: 39477867, DOI: 10.1007/s11606-024-09178-8.Peer-Reviewed Original ResearchAltmetricGLP-1 programs the neurovascular landscape
Chen B, Yu X, Horvath-Diano C, Ortuño M, Tschöp M, Jastreboff A, Schneeberger M. GLP-1 programs the neurovascular landscape. Cell Metabolism 2024, 36: 2173-2189. PMID: 39357509, DOI: 10.1016/j.cmet.2024.09.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGLP-1R agonismGLP-1RMetabolic healthChronic low-grade inflammationLow-grade inflammationGlucagon-like peptide-1 receptorPersistent health issuesCognitive well-beingNutrient-rich foodsPeptide-1 receptorMetabolic syndromeHealth issuesMetabolic defectsBrain healthMetabolic environmentObesityWell-beingWeight lossHealthMetabolic conditionsAgonismNeurological conditionsConsiderations for the design and conduct of pediatric obesity pharmacotherapy clinical trials: Proceedings of expert roundtable meetings
Kelly A, Bahlke M, Baker J, de Beaufort C, Belin R, Fonseca H, Hale P, Holm J, Hsia D, Jastreboff A, Juliusson P, Murphy M, Pak J, Paul E, Rudolph B, Srivastava G, Tornøe C, Weghuber D, Fox C. Considerations for the design and conduct of pediatric obesity pharmacotherapy clinical trials: Proceedings of expert roundtable meetings. Pediatric Obesity 2024, 19: e13161. PMID: 39289849, DOI: 10.1111/ijpo.13161.Peer-Reviewed Original ResearchAltmetricConceptsAnti-obesity medicationsExcessive weight reductionClinical trialsEnd pointsDown-titrationEligibility criteriaLong-term health outcomesBMI z-scoreActive comparatorEfficacy end pointPlacebo-controlled trialSecondary end pointsRun-in phaseFollow-up periodFollow-up phaseHealth outcomesObesity expertsTrial eligibility criteriaClinical careWeight reductionMultidisciplinary groupClinical trial protocolsPrimary outcomeWeight regainTrial protocolSemaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial
Deanfield J, Verma S, Scirica B, Kahn S, Emerson S, Ryan D, Lingvay I, Colhoun H, Plutzky J, Kosiborod M, Hovingh G, Hardt-Lindberg S, Frenkel O, Weeke P, Rasmussen S, Goudev A, Lang C, Urina-Triana M, Pietilä M, Lincoff A, Investigators S, Abe M, Abhaichand R, Abhayaratna W, Abhyankar A, Abidin I, Assi H, Mendoza J, Adas M, Agaiby J, Agarwal D, Agha M, Ahmed A, Ahtiainen P, Aigner E, Ajay N, Ali N, Al-Karadsheh A, Allison R, Allison D, Alpenidze D, Altuntas Y, Al-Zoebi A, Ambuj R, Amerena J, Anderson R, Ando T, Andrews R, Antonova E, Appel K, Arantes F, Araz M, Arbel Y, León J, Argyrakopoulou G, Ariani M, Mendoza M, Arif A, Arneja J, Aroda V, Aronne L, Arstall M, Asamoah N, Asanin M, Audish H, Avram R, Badat A, Badiu C, Bakdash W, Bakiner O, Bandezi V, Bang L, Bansal S, Baranyai M, Barbarash O, Barber M, Barnum O, Rochette G, Bashkin A, Baum S, Bays H, Ruiz A, Beckowski M, Beerachee Y, Bellary S, Belousova L, Berk M, Bernstein M, Berra C, Beshay I, Bhagwat A, Bhan A, Biggs W, Billings L, Bitar F, Block B, Bo S, Bogdanski P, Bolshakova O, Boshchenko A, Bosworth H, Lopez R, Bôttcher M, Bourgeois R, Brautigam D, Breton C, Broadley A, Brockmyre A, Brodie S, Bucci M, Budincevic H, Budoff M, Buffman B, Buljubasic N, Buranapin S, Burgess L, Burguera B, Buriakovska O, Buscemi S, Busch R, Buse J, Buynak R, Byrne M, Caceaune E, Bonfanti A, Calinescu C, Call R, Varzic S, Cannon K, Capehorn M, Cariou B, Carr J, Carrillo-Jimenez R, Casas M, Castro A, Celik A, Cercato C, Cermak O, Y J, Chacon C, Chaicha-Brom T, Chandra S, Chettibi M, Chevts J, Christopher J, Chrustowski W, Cif A, Clark R, Clark W, Clifford P, Coetzee K, Cogni G, Colao A, Colquhoun D, Concha M, Condit J, Constance C, Constantin C, Constantinescu S, Corbett C, Cornett G, Correia M, Cortinovis F, Cosma D, Creely S, Cross D, Curtis B, Czochra W, Daboul N, Dagdelen S, D'agostino R, Dang C, Datta S, Davuluri A, Dawood S, De Jong D, De La Cuesta C, De Los Rios Ibarra M, De Pablo C, De Pauw M, Dela Llana A, Delibasic M, Delic-Brkljacic D, Demicheli T, Denger R, Desai D, Desai P, Desouza C, Dicker D, Djenic N, Dobson S, Doi M, Doran J, Dorman R, Dotta F, Dukes C, Duronto E, Durst R, Dvoryashina I, Ebrahim I, Eggebrecht H, Egstrup K, Ekinci E, Eliasson B, Eliasson K, Enache G, Enculescu D, English P, Ermakova P, Ershova O, Ezaki H, Ezhov M, Farias E, Farias J, Farsky P, Ferreira D, Filteau P, Finneran M, Folkens E, Fonseca A, Fonseca L, Fordan S, Fourie N, França S, Franco D, Franek E, Friedman K, Frittitta L, Froer M, Fuckar K, Fujii K, Fujita R, Fukushima Y, Fulat M, Fulwani M, Gajos G, Galyavich A, Gambill M, Gandotra D, Winston G, Hernandez P, Reza R, Garg N, Garg S, Garvey W, Garza J, Gatta-Cherifi B, Gelev V, Geller S, Geohas J, Georgiev B, Ghazi A, Gilbert M, Gilinskaya O, Gislason G, Yavuz D, Albarrán O, Gordeev I, Gorton S, Goudev A, Valderhaug T, Groenemeijer B, Gul I, Gullestad L, Gurieva I, Guseva G, Hagenow A, Haluzik M, Halvorsen S, Hammoudi N, Hanaoka K, Hancu N, Hanusch U, Harris K, Harris B, Hartleib M, Hartman A, Hata Y, Heimer B, Herman L, Herzog W, Hewitt E, Heymer P, Hiremath S, Hjelmesaeth J, Høgalmen R, Høivik H, Holmer H, Horoshko O, Houser P, Hove J, Hsieh I, Hulot J, Hussein Z, Ilashchuk T, Ilveskoski E, Ipatko I, Iranmanesh A, Isawa T, Issa M, Iteld B, Iwasawa T, Jabbar D, Jackson R, Jackson-Voyzey E, Jacob S, Jaffrani N, Jardula M, Jastreboff A, Jensen S, Jerkins T, Jimenez-Ramos S, Singh S, Johnson W, Joyce J, Jozefowska M, Jugnundan P, Jungmair W, Jurowiecki J, Kadokami T, Kahali D, Kahrmann G, Kaiser S, Kalmucki P, Kanadasi M, Kandath D, Kania G, Kannan J, Kapp C, Karczmarczyk A, Kartalis A, Kaser S, Kasim S, Kastelic R, Kato T, Katova T, Kaul U, Kautzky-Willer A, Kawanishi M, Kayikcioglu M, Kazakova E, Keeling P, Kempe H, Kereiakes D, Kerneis M, Keski-Opas T, Khadra S, Khaisheva L, Kharakhulakh M, Khlevchuk T, Khoo J, Kiatchoosakun S, Kinoshita N, Kinoshita M, Kitamura R, Kiyosue A, Klavina I, Klein E, Klimsa Z, Klonoff D, Klug E, Kobalava Z, Kodera S, Koga T, Kokkinos A, Koleckar P, Könyves L, Koren M, Kormann A, Kostner K, Kreutzmann K, Krishinan S, Krishnasamy S, Krivosheeva I, Kruljac I, Kubicki T, Kuchar L, Kujawiak M, Kunishige H, Kurtinecz M, Lisboa H, Kushnir M, Kyyak Y, Lace A, Lakka T, Lalic N, Lalic K, Lambadiari V, Lanaras L, Lang C, Langlois M, Lash J, Latkovskis G, Lau D, Soto J, Le Roux C, Ledesma G, Lee L, Lee T, Lee K, Lehrke M, Leite S, Leksycka A, Lenzmeier T, Leonetti F, Leonidova V, Lepor N, Leung M, Levchenko O, Levins P, Levy L, Lewis M, Liberopoulos E, Liberty I, Lindholm C, Lingvay I, Linhart A, Liu M, Liu J, Lofton H, Logemann T, Lombaard J, Lombard L, Lorraine R, Lovell C, Ludvik B, Lukaszewicz M, Lupkovics G, Lupovitch S, Lupu S, Lynch M, Lysak Z, Lysenko T, Maeda H, Maeda I, Mæng M, Mahajan A, Maher V, Maia L, Makotoko E, Malavazos A, Malecha J, Malicherova E, Manita M, Mannucci E, Mareev V, Marin L, Markova T, Marso S, Martens F, Martinez C, Cano C, Martins C, Comas L, Matsumoto T, Mcdonald K, Mcgowan B, Mcgrew F, Mclean B, Mcpherson D, Torres J, Meyers P, Meyhöfer S, Raya P, Milanova M, Milicic D, Miller G, Mills R, Mîndrescu N, Mingrone G, Minkova D, Mirani M, Miras A, Mistodie C, Mitomo S, Mittal S, Miyake T, Miyamoto N, Molony D, Monteiro P, Mooe T, Moosa N, Portillo C, Villegas E, Morawski E, Morbey C, Morin R, Morisaki K, Morosanu M, Mosenzon O, Mostovoy Y, Munir I, Muratori F, Murray R, Murthy A, Myint M, Myshanych G, Nafornita V, Nagano T, Nair S, Nakhle S, Natsuaki M, Nayak B, Nibouche D, Nicholls S, Nicolau J, Nicolescu G, Nierop P, Niskanen L, Ntaios G, Nygård O, Oaks J, Obrezan A, O'donnell P, Oguri M, Oguzhan A, Oh F, Ohsugi M, Okada Y, Okayama H, Onaca A, Onaka H, Oneil P, Ong T, Ong S, Ono Y, Opsahl P, Ostrowska L, Oviedo A, Ozdogan O, Ozpelit E, Pagkalos E, Pagotto U, Páll D, Pandey A, Parkhomenko O, Parvathareddy K, Patel M, Patsilinakos S, Paul N, Pedersen S, Pereira I, Pereira E, Terns P, Perez-Vargas E, Pergaeva Y, Perkelvald A, Peskov A, Peter J, Peters K, Petit C, Petrov I, Philis-Tsimikas A, Pietilä M, Pinto F, Piros A, Piyayotai D, Platonov D, Poirier P, Pop L, Popa B, Pop-Busui R, Poremba J, Porto A, Postadzhiyan A, Pothineni R, Potu R, Powell T, Prafulla K, Prager R, Prakova-Teneva Z, Pratley R, Price H, Pulka G, Pullman J, Punt Z, Purighalla R, Purnell P, Qureshi M, Rabasa-Lhoret R, Raikhel M, Rancane G, Randeva H, Rasouli N, Pintilei D, Reyes C, Rezgale I, Rice E, Riley T, Risser J, Ristic A, Fernández M, Robbins D, Robitaille Y, Rodbard H, Plazas J, Römer T, Rosen G, Rosman A, Rossi P, Rudenko L, Ruffin O, Ruhani A, Runev N, Ruyatkin D, Ruzic A, Ryabov V, Rydén L, Saggar S, Sakamoto T, Salter T, Samal A, Samoilova Y, Sanabria H, Sancak S, Sangrigoli R, Sansanayudh N, Santini F, Saraiva J, Sardinov R, Sargeant W, Sari R, Sathananthan A, Sathyapalan T, Sato A, Sauter J, Sbraccia P, Schaap J, Schaum T, Schiele F, Scott J, Lieberman G, Segner A, Senior R, Sergeeva-Kondrachenko M, Serota H, Serusclat P, Sethi R, Shah M, Shah N, Shalaev S, Sharma R, Sharma S, Shaydyuk O, Shea H, Shechter M, Shehadeh N, Shirazi M, Shlesinger Y, Shneker A, Shutemova E, Siasos G, Siddiqui I, Sidey J, Sigal F, Sime I, Singh N, Siraj E, Sivalingam K, Skoczylas G, Smith S, Smolenskaya O, Snyder B, Sofer Y, Sofley C, Solano R, Sonmez Y, Sorokin M, González A, Sotolongo C, Soufer J, Selcukbiricik O, Spaic T, Spriggs D, Sreenan S, Stahl H, Stamatelopoulos K, Stanislavchuk M, Stankovic G, Stasek J, Steg G, Steindorf J, Stephan D, Stewart J, Still C, St-Maurice F, Stogowska-Nikiciuk B, Stoker J, Stokic E, Strzelecka A, Sturm K, Sueyoshi A, Sugiura T, Sultan S, Suplotova L, Suwanagool A, Suwanwalaikorn S, Sveklina T, Swanson N, Swart H, Swenson B, Szyprowska E, Tait G, Takács R, Takeuchi Y, Tamirisa A, Tanaka H, Tatovic D, Tellier G, Teragawa H, Teterovska D, Thomas N, Thuan J, Tinahones F, Tisheva-Gospodinova S, Toarba C, Todoriuk L, Tokmakova M, Tonstad S, Toplak H, Tran H, Tripathy D, Trusau A, Tsabedze N, Tsougos E, Tsoukas G, Tuccinardi D, Tuna M, Turatti L, Tziomalos K, Udommongkol C, Ueda O, Ukkola O, Unubol M, Urbach D, Triana M, Usdan L, Vaidya B, Vale N, Vallieres G, Van Beek A, Van De Borne P, Van Der Walt E, Van Der Zwaan C, Van Nieuwenhuizen E, Van Zyl L, Vanduynhoven P, Varghese K, Vasileva S, Vassilev D, Vathesatogkit, Velychko V, Vercammen C, Verges B, Verma S, Verwerft J, Vesela A, Veselovskaya N, Vettor R, Veze I, Vijan V, Vijayaraghavan R, Villarino A, Vincent R, Vinogradova O, Vishlitzky V, Vlad A, Vladu I, Vo A, Von Engelhardt C, Von Münchhausen C, Vorobyeva O, Vossenberg T, Vrolix M, Vukicevic M, Vyshnyvetskyy I, Wadvalla S, Wagner J, Wakeling J, Wallace J, Mohamed W, Wander G, Ward K, Warren M, Watanabe A, Weber B, Weintraub H, Weisnagel J, Welker J, Wendisch U, Wenocur H, Wierum C, Wilding J, William M, Wilson P, Wilson J, Wong Y, Wongcharoen W, Wozniak I, Wu C, Wyatt N, Wynne A, Yamaguchi H, Yamasaki M, Yazici D, Yeh H, Yotov Y, Yuan Q, Zacher J, Zagrebelnaya O, Zaidman C, Zalevskaya A, Zarich S, Zatelli M, Zeller H, Zhdanova E, Zornitzki T, Zrazhevskiy K, Zykov M, Lincoff A, Ryan D, Colhoun H, Deanfield J, Emerson S, Kahn S, Kushner R, Plutzky J, Brown-Frandsen K, Hovingh G, Hardt-Lindberg S, Tornøe C. Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial. The Lancet 2024, 404: 773-786. PMID: 39181597, DOI: 10.1016/s0140-6736(24)01498-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsReduced ejection fractionOnce-weekly subcutaneous semaglutideHistory of heart failureEjection fractionHeart failureHeart failure subtypesAtherosclerotic cardiovascular diseaseSubcutaneous semaglutideBaseline characteristicsCardiovascular diseaseEffects of once-weekly subcutaneous semaglutideNew York Heart Association statusCardiovascular outcomesInteractive web response systemIncidence of clinical eventsGLP-1 receptor agonistsHeart failure endpointsSafety of semaglutideSubtypes of heart failureWeb response systemClinical heart failureEffect of semaglutideDouble-blind mannerSerious adverse eventsPhase 3 trialEnding Weight Stigma to Advance Health Equity
Pearl R, Donze L, Rosas L, Agurs-Collins T, Baskin M, Breland J, Byker Shanks C, Cooksey Stowers K, Johnson S, Lee B, Martin M, Mujuru P, Odoms-Young A, Panza E, Pronk N, Calicutt K, Nadglowski J, Nece P, Tedder M, Chow L, Krishnamurti H, Jay M, Xi D, Jastreboff A, Stanford F. Ending Weight Stigma to Advance Health Equity. American Journal Of Preventive Medicine 2024, 67: 785-791. PMID: 38945180, DOI: 10.1016/j.amepre.2024.06.021.Peer-Reviewed Original ResearchAltmetricEffect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial
Kahn S, Deanfield J, Jeppesen O, Emerson S, Boesgaard T, Colhoun H, Kushner R, Lingvay I, Burguera B, Gajos G, Horn D, Hramiak I, Jastreboff A, Kokkinos A, Maeng M, Matos A, Tinahones F, Lincoff A, Ryan D, Investigators S. Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial. Diabetes Care 2024, 47: 1350-1359. PMID: 38907683, PMCID: PMC11282386, DOI: 10.2337/dc24-0491.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCardiovascular diseaseMagnitude of weight reductionDouble-blind trialEffect of semaglutideCases of diabetesSubcutaneous semaglutideTreatment armsFollow-upSemaglutideDiabetesHbA1cObesityIntervention exposureGlycemiaPlaceboWeeksBody weightGlycemic outcomesDiseaseWeight reductionNormoglycemiaTrialsParticipantsProgressionKg/m2DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases
Handelsman Y, Anderson J, Bakris G, Ballantyne C, Bhatt D, Bloomgarden Z, Bozkurt B, Budoff M, Butler J, Cherney D, DeFronzo R, Del Prato S, Eckel R, Filippatos G, Fonarow G, Fonseca V, Garvey W, Giorgino F, Grant P, Green J, Greene S, Groop P, Grunberger G, Jastreboff A, Jellinger P, Khunti K, Klein S, Kosiborod M, Kushner P, Leiter L, Lepor N, Mantzoros C, Mathieu C, Mende C, Michos E, Morales J, Plutzky J, Pratley R, Ray K, Rossing P, Sattar N, Schwarz P, Standl E, Steg P, Tokgözoğlu L, Tuomilehto J, Umpierrez G, Valensi P, Weir M, Wilding J, Wright E. DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases. Metabolism 2024, 159: 155931. PMID: 38852020, DOI: 10.1016/j.metabol.2024.155931.Peer-Reviewed Original ResearchCitationsAltmetricConceptsChronic kidney diseaseAtherosclerotic cardiovascular diseaseHeart failureMetabolic diseasesCardiorenal risk factorsEssentials of managementPractice recommendationsType 2 diabetesImprove patient outcomesVolunteer task forcePrimary care physiciansMetabolic comorbiditiesMultispecialty consensusOutcome trialsManagement of personsKidney diseaseLiver diseasePathophysiological pathwaysPulmonary diseaseRisk factorsSteatotic liver diseaseManagement of diabetesCardiovascular diseasePatient outcomesCare physicians
Clinical Trials
Current Trials
EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
HIC ID2000032942RolePrincipal InvestigatorPrimary Completion Date09/30/2024Recruiting ParticipantsGenderBothAge6 years - 65 yearsGLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weight
HIC ID2000027868RolePrincipal InvestigatorPrimary Completion Date06/30/2025Recruiting ParticipantsGenderBothAge18 years - 55 years
Academic Achievements & Community Involvement
activity The Obesity Society
Peer Review Groups and Grant Study SectionsReviewerDetailsGrant Reviewer (Scientific Review Committee)2017 - Presentactivity The Endocrine Society
Professional OrganizationsCommittee MemberDetailsHormone Health Network (HHN) committee2019 - Presentactivity ADA (American Diabetes Association)
Meeting Planning and ParticipationMemberDetailsObesity/Pathogenesis of Obesity Subcommittee07/01/2019 - Presentactivity Obesity - National Childhood Obesity Awareness Month Special Issue
Journal ServiceAssociate EditorDetails06/01/2021 - Presentactivity Diabetes Care
Journal ServiceAssociate EditorDetails2022 - Present
Clinical Care
Overview
Ania M. Jastreboff, MD, PhD, is an adult and pediatric endocrinologist with expertise in obesity medicine and weight management. She cares for patients who have prediabetes, insulin resistance, metabolic syndrome, and type 1 and type 2 diabetes.
Dr. Jastrebroff, who is director of the Yale Obesity Research Center (Y-Weight), says she empathizes with patients who struggle to lose weight or maintain weight loss. “Carrying excess weight and having obesity is not a lifestyle choice. Obesity is a chronic disease and should be treated with the same vigor and integrity as other chronic diseases,” she says. “We are in the infancy of our understanding of the mechanisms that underlie obesity. Many novel treatments are under development, including new anti-obesity medications, endoscopic procedures, and the refining of behavioral and surgical interventions.”
An assistant professor of medicine (endocrinology) and of pediatrics (endocrinology) at Yale School of Medicine, Dr. Jastrebroff says one of her goals is to conduct clinic research that will lead to better treatments for obesity and also have a clear public health impact in mitigating the obesity “pandemic.”
Clinical Specialties
Fact Sheets
Diabetes: Symptoms, Causes, and Treatments
Learn More on Yale Medicine
Board Certifications
Obesity Medicine
- Certification Organization
- AB of Obesity Medicine
- Original Certification Date
- 2016
Endocrinology Diabetes & Metabolism
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2012
Yale Medicine News
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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News
- November 22, 2024Source: Yahoo
Health headlines: Can GLP-1 drugs reverse prediabetes?
- November 18, 2024Source: Health Day
Tirzepatide Yields Sustained Weight Reduction in Obesity, Prediabetes
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
- September 19, 2024Source: Yale Insights
Ania Jastreboff: The Transformative Obesity Drugs
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.