2023
Uncovering biology by single-cell proteomics
Mansuri M, Williams K, Nairn A. Uncovering biology by single-cell proteomics. Communications Biology 2023, 6: 381. PMID: 37031277, PMCID: PMC10082756, DOI: 10.1038/s42003-023-04635-2.Peer-Reviewed Original Research
1997
Phosphorylation of Connexin43 and the Regulation of Neonatal Rat Cardiac Myocyte Gap Junctions
Sáez J, Nairn A, Czernik A, Fishman G, Spray D, Hertzberg E. Phosphorylation of Connexin43 and the Regulation of Neonatal Rat Cardiac Myocyte Gap Junctions. Journal Of Molecular And Cellular Cardiology 1997, 29: 2131-2145. PMID: 9281445, DOI: 10.1006/jmcc.1997.0447.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalcium-Calmodulin-Dependent Protein KinasesCDC2 Protein KinaseCells, CulturedConnexin 43DNA, ComplementaryElectrophoresis, Gel, Two-DimensionalEnzyme InhibitorsGap JunctionsMyocardiumPatch-Clamp TechniquesPhosphorylationProtein Processing, Post-TranslationalRatsRecombinant Fusion ProteinsStaurosporineTetradecanoylphorbol AcetateConceptsProtein kinase CTwo-dimensional tryptic phosphopeptide mapsTryptic phosphopeptide mapsState of phosphorylationMyocyte gap junctionsProtein kinase inhibitorsGap junctionsMajor gap junction proteinPhosphorylation of connexin43Gap junction proteinPhosphopeptide mapsTryptic phosphopeptidesPKC-dependent mechanismFunctional couplingPhosphorylated formKinase CPhosphorylationNeonatal rat cardiocytesCx43 phosphorylationStaurosporineCellular distributionImmunoblot analysisRat cardiocytesJunction proteinsCx43
1993
Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer β/A4 Amyloid Precursor Proteina
GANDY S, CAPORASO G, BUXBAUM J, DA CRUZ E SILVA O, IVERFELDT K, NORDSTEDT C, SUZUKI T, CZERNIK A, NAIRN A, GREENGARD P. Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer β/A4 Amyloid Precursor Proteina. Annals Of The New York Academy Of Sciences 1993, 695: 117-121. PMID: 8239268, DOI: 10.1111/j.1749-6632.1993.tb23038.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAmyloid beta-Protein PrecursorAnimalsHumansPC12 CellsPhosphoproteinsPhosphorylationProtein Processing, Post-TranslationalSerineConceptsOkadaic acid-sensitive proteinAlzheimer amyloid precursor proteinAcid-sensitive proteinProtein kinase CProtein phosphorylationKinase CCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IIProtein kinase IISignal transductionPhosphorylation stateModulation of betaKinase IISecretory cleavageSubstrate redistributionPrecursor proteinCurrent experimental evidenceAmyloid precursor proteinProteinCleavage pathwayPhosphorylationProcessing pathwaysSubstrate activationSer655APP metabolism
1992
Characterization of Alternative Routes for Processing of the Alzheimer β/A4‐Amyloid Precursor Protein
GANDY S, CAPORASO G, RAMABHADRAN T, SUZUKI T, BUXBAUM J, NORDSTEDT C, IVERFELDT K, CZERNIK A, NAIRN A, GREENGARD P. Characterization of Alternative Routes for Processing of the Alzheimer β/A4‐Amyloid Precursor Protein. Annals Of The New York Academy Of Sciences 1992, 674: 203-217. PMID: 1363189, DOI: 10.1111/j.1749-6632.1992.tb27489.x.Peer-Reviewed Original ResearchAlzheimer DiseaseAmino Acid SequenceAmyloid beta-Protein PrecursorAmyloidosisAnimalsBrain DiseasesEndopeptidasesHumansMolecular Sequence DataProtein Processing, Post-Translational
1990
Role of Ca2+/calmodulin-dependent protein phosphorylation in signal transduction.
Nairn A. Role of Ca2+/calmodulin-dependent protein phosphorylation in signal transduction. 1990, 24: 202-5. PMID: 1976329.Peer-Reviewed Original Research
1986
Protein phosphorylation in cultured endothelial cells
Mackie K, Lai Y, Nairn A, Greengard P, Pitt B, Lazo J. Protein phosphorylation in cultured endothelial cells. Journal Of Cellular Physiology 1986, 128: 367-374. PMID: 3745280, DOI: 10.1002/jcp.1041280304.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCattleCells, CulturedEndotheliumLungPhosphoproteinsPhosphorylationProtein KinasesProtein Processing, Post-TranslationalProteinsSubstrate SpecificityConceptsCalcium/calmodulin-dependent protein kinaseCalmodulin-dependent protein kinaseCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseProtein kinase activityProtein kinaseKinase activityCyclic GMP-dependent protein kinase activityRespective substrate proteinsProtein phosphorylation systemsProtein kinase CSubstrate proteinsProtein phosphorylationPhosphorylation systemEndothelial cellsNumerous substratesTyrosine kinaseKinase CPulmonary artery endothelial cellsKinaseCultured endothelial cellsArtery endothelial cellsSimilar culture conditionsCulture conditionsCells