2022
Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning.
Paulson N, Zeevi T, Papademetris M, Leapman MS, Onofrey JA, Sprenkle PC, Humphrey PA, Staib LH, Levi AW. Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning. JCO Clinical Cancer Informatics 2022, 6: e2200016. PMID: 36179281, DOI: 10.1200/cci.22.00016.Peer-Reviewed Original ResearchConceptsGrade group 2Prostate biopsyRadical prostatectomyAdverse outcomesGroup 2GG-2Core prostate biopsyProstate cancer outcomesPatient's clinical riskClinical risk assessmentCore needle biopsyOngoing clinical needAdverse outcome predictionRetrospective reviewAdverse pathologyCAPRA scoreEntire cohortCancer outcomesPathologic diagnosisNeedle biopsyClinical riskDisease outcomeProstate cancerBiopsyDisease one
2021
Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage.
Paulson N, Vollmer RT, Humphrey PA, Sprenkle PC, Onofrey J, Huber S, Amirkhiz K, Levi AW. Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage. Archives Of Pathology & Laboratory Medicine 2021, 146: 201-204. PMID: 34015819, DOI: 10.5858/arpa.2020-0568-oa.Peer-Reviewed Original ResearchConceptsMpMRI-targeted biopsiesHigh-grade prostatic adenocarcinomaMultiparametric magnetic resonance imagingHG PCaRadical prostatectomyHigh-grade groupMagnetic resonance imagingPathologic stageRP outcomesProstatic adenocarcinomaGrade Group 2 diseaseResonance imagingGrade groupProstate-confined diseaseSeminal vesicle involvementLymph node metastasisHigher pathologic stageAdditional predictive valueLogistic regression modelsLinear millimeterNode metastasisRetrospective reviewAdverse outcomesTargeted biopsiesProstate biopsyAn independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy
Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.Peer-Reviewed Original ResearchConceptsMemorial Sloan-Kettering Cancer CenterCore biopsyPredictive valueDiagnostic accuracyProstate core needle biopsiesCore needle biopsySurgical pathology practiceNegative predictive valueProstate core biopsiesPositive predictive valueProstate cancer detectionStrong diagnostic accuracyPoor quality scansCancer detectionCancer CenterProstate biopsyLeading causeNeedle biopsyTransrectal approachProstate cancerProstatic adenocarcinomaProstate carcinomaBiopsyPathology practiceProstate
2018
Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies
Martin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2018, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.Peer-Reviewed Original ResearchConceptsPI-RADSv2 scoreDecipher scoreProstate Imaging ReportingDecipher testingTargeted biopsiesRadical prostatectomyData System version 2 (PI-RADS v2) scoreFavorable intermediate-risk prostate cancerIntermediate-risk prostate cancer patientsGleason Grade Group 1Imaging ReportingIntermediate-risk prostate cancerMultivariable logistic regression analysisHigh-risk diseasePI-RADS 4Grade group 1Gleason grade groupProstate cancer patientsMultiparametric magnetic resonancePI-RADS scoreVersion 2 scoreData System scoreLogistic regression analysisSignificant differencesPI-RADS category
2017
Prostate zonal anatomy correlates with the detection of prostate cancer on multiparametric magnetic resonance imaging/ultrasound fusion–targeted biopsy in patients with a solitary PI-RADS v2–scored lesion
Syed JS, Nguyen KA, Nawaf CB, Bhagat AM, Huber S, Levi A, Humphrey P, Weinreb JC, Schulam PG, Sprenkle PC. Prostate zonal anatomy correlates with the detection of prostate cancer on multiparametric magnetic resonance imaging/ultrasound fusion–targeted biopsy in patients with a solitary PI-RADS v2–scored lesion. Urologic Oncology Seminars And Original Investigations 2017, 35: 542.e19-542.e24. PMID: 28501565, DOI: 10.1016/j.urolonc.2017.04.011.Peer-Reviewed Original ResearchConceptsPositive predictive valueProstate cancerGleason scoreSuspicious findingsMultiparametric magnetic resonance imagingProstate multiparametric magnetic resonance imagingPeripheral zoneHigh positive predictive valueFusion-targeted biopsyProstate Imaging ReportingPI-RADS v2Category 4 lesionsMagnetic resonance imagingProstate zonal anatomySystematic biopsyProstate biopsyFusion biopsySingle lesionPatientsBiopsyPredictive valueImaging ReportingResonance imagingLesionsCancerNegative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy
Lu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingSignificant prostate cancerProstate cancerNegative predictive valueMagnetic resonance imagingSystematic TRUSNegative mpMRIProstate biopsyNegative multiparametric magnetic resonance imagingPredictive valueResonance imagingClinically Significant Prostate CancerDynamic contrast enhancement sequencesTemplate mapping biopsyPrior negative biopsySystematic prostate biopsyOverall cancer detectionProstate-specific antigenTemplate prostate biopsyProstate cancer detectionDiffusion-weighted imagingCancer detectionBiopsy naïveMapping biopsyProstate volume
2015
Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin
Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D. Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin. American Journal Of Clinical Pathology 2015, 143: 694-700. PMID: 25873503, DOI: 10.1309/ajcpcza4pszcfhq4.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCobas 4800 systemRoche cobas 4800 systemMetastatic squamous cell carcinomaFine needle aspiratesHuman papillomavirusHR-HPVCell carcinomaHPV 16High-risk (HR) HPVSquamous cell carcinoma originatingHigh-risk human papillomavirusNeck squamous cell carcinomaHPV 16/18 genotypesHR-HPV testingHR-HPV detectionHR-HPV resultsCorresponding histologic specimensLeft parapharyngeal massElectronic health recordsCarcinoma originatingMediastinal lymphadenopathyNegative HNSCCProspective studyHistologic material
2009
Prenatal diagnosis of an umbilical vein aneurysm: a case report.
Panda B, Stiller R, Iruretagoyena I, Levi A. Prenatal diagnosis of an umbilical vein aneurysm: a case report. Connecticut Medicine 2009, 73: 465-7. PMID: 19777980.Peer-Reviewed Original Research
2004
Urinary bladder biopsy with denuded mucosa: Denuding cystitis—Cytopathologic correlates
Parwani AV, Levi AW, Epstein JI, Ali SZ. Urinary bladder biopsy with denuded mucosa: Denuding cystitis—Cytopathologic correlates. Diagnostic Cytopathology 2004, 30: 297-300. PMID: 15108225, DOI: 10.1002/dc.10406.Peer-Reviewed Original ResearchConceptsHigh-grade urothelial carcinomaUrothelial carcinomaUrinary cytologyFollowing histologic subtypesUrinary bladder biopsiesPositive urinary cytologySurgical pathology filesInvasive urothelial carcinomaOptimal patient managementRecurrent urothelial carcinomaJohns Hopkins HospitalPatient agePathology filesHistologic subtypeBladder biopsiesHistologic diagnosisBladder mucosaFlat carcinomaSensitive modalityPatient managementCytologic diagnosisCystitisCytologic studyTissue biopsiesPatients
2003
Mollaret's meningitis: Cytopathologic analysis of fourteen cases
Chan TY, Parwani AV, Levi AW, Ali SZ. Mollaret's meningitis: Cytopathologic analysis of fourteen cases. Diagnostic Cytopathology 2003, 28: 227-231. PMID: 12722116, DOI: 10.1002/dc.10261.Peer-Reviewed Original ResearchConceptsMollaret's meningitisRecurrent episodesPolymerase chain reactionPolymorphonuclear leukocytesMost common clinical presentationCerebrospinal fluid examinationCommon clinical presentationAppropriate clinical settingSmall mature lymphocytesHerpes simplex virus type 2 DNAHemosiderin-laden macrophagesCentral nervous systemVirus type 2 DNASole diagnostic modalityAseptic meningitisCSF examinationFluid examinationClinical presentationLymphoproliferative disordersMild feverClinical dataCytopathologic analysisDifferential diagnosisPlasma cellsDiagnostic modalities
2001
The pigmented “black” neuroendocrine tumor of the pancreas
Sehdev A, Levi A, Nadasdy T, Campbell K, Fishman E, Hruban R. The pigmented “black” neuroendocrine tumor of the pancreas. Cancer 2001, 92: 1984-1991. PMID: 11745274, DOI: 10.1002/1097-0142(20011001)92:7<1984::aid-cncr1718>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsMetastatic melanomaNeuroendocrine tumorsNeoplastic cellsIron stainIslet cell tumorsFontana-Masson stainPerineural invasionSecond patientHMB-45Large neoplasmsAdrenal glandCell tumorsIncidental findingBlack adenomaImmunohistochemical stainsPancreatic neoplasmsComputerized tomographySmall lipid inclusionsNeoplasmsTumorsPatientsUltrastructural examinationNeurosecretory granulesPancreasFontana-MassonCLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY
LEVI A, POTTER S, SCHOENBERG M, EPSTEIN J. CLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY. Journal Of Urology 2001, 166: 457-460. PMID: 11458047, DOI: 10.1016/s0022-5347(05)65963-0.Peer-Reviewed Original ResearchConceptsCold cup biopsyHistory of carcinomaCup biopsyBladder biopsiesSubsequent carcinomaPertinent clinical featuresTissue fragmentsLow-grade papillary tumorsSpecific pathological featuresDiagnosis of carcinomaBenign urothelial cellsCystoscopic impressionPatients 22Intravesical chemotherapyClinical featuresBladder lesionsBladder neoplasmsPredictive factorsLoop biopsyPapillary tumorsPathological featuresTissue inflammationBladder carcinomaEpithelial denudationMiscellaneous conditions
2000
Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy
Levi A, Epstein J. Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy. The American Journal Of Surgical Pathology 2000, 24: 1039-1046. PMID: 10935644, DOI: 10.1097/00000478-200008000-00001.Peer-Reviewed Original ResearchConceptsNeedle biopsyProstatic adenocarcinomaSimple prostatectomyMalignant diagnosisHigh molecular weight keratinSurgical pathology filesBenign hyperplastic glandsJohns Hopkins HospitalDiagnosis of cancerPathology filesTransurethral resectionPapillary infoldingsHyperplastic glandsAtypical glandsImmunohistochemical stainsConsult casesWeight keratinBiopsyCorpora amylaceaFrequent nucleoliHistologic attributesAdenocarcinomaBenign featuresCancerNuclear enlargement