2021
Rab27a-Dependent Paracrine Communication Controls Dendritic Spine Formation and Sensory Responses in the Barrel Cortex
Zhang L, Zhang X, Hsieh LS, Lin TV, Bordey A. Rab27a-Dependent Paracrine Communication Controls Dendritic Spine Formation and Sensory Responses in the Barrel Cortex. Cells 2021, 10: 622. PMID: 33799820, PMCID: PMC8000154, DOI: 10.3390/cells10030622.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDendritic SpinesExcitatory Postsynaptic PotentialsExtracellular VesiclesFemaleGene Expression Regulation, DevelopmentalGestational AgeMiceParacrine CommunicationPregnancyPyramidal CellsRab27 GTP-Binding ProteinsSensory Receptor CellsSomatosensory CortexSynaptic TransmissionVibrissaeConceptsSmall extracellular vesiclesL4 neuronsParacrine communicationExcitatory synaptic transmissionRelease of sEVsDendritic spine formationCell-autonomous effectsRisk of autismL2/3 neuronsPyramidal neuronsLayer 2/3Somatosensory cortexBarrel cortexCortical neuronsSynaptic transmissionWhisker stimulationSomatosensory informationJuvenile miceSynaptic connectivitySynaptic integrationSpine formationBrain developmentNeuronsSensory stimulationSpine development
2004
Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons
Huang H, Bordey A. Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons. Journal Of Neuroscience 2004, 24: 5659-5669. PMID: 15215288, PMCID: PMC6729224, DOI: 10.1523/jneurosci.1338-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid Transport System X-AGAnimalsAntiportersCalciumCerebellumCystineEvoked PotentialsGamma-Aminobutyric AcidGlutamic AcidIn Vitro TechniquesMiceNerve FibersNeural InhibitionNeurogliaPatch-Clamp TechniquesPurkinje CellsReceptors, N-Methyl-D-AspartateReceptors, PresynapticRyanodineSynaptic TransmissionConceptsGlial glutamate transportersMiniature IPSCsPurkinje neuronsGlutamate transportersSpontaneous IPSCsSynaptic inhibitionInhibitory synapsesNMDAR activationWhole-cell patch-clamp recordingsPresynaptic NMDA receptorsPaired-pulse ratioMouse cerebellar slicesNMDA receptor activationPresynaptic NMDA receptor activationPatch-clamp recordingsBergmann glial cellsBeta-benzyloxyaspartic acidAdjacent Purkinje neuronsCystine-glutamate antiporterMIPSC frequencyGABAergic terminalsGABAergic synapsesGlial cellsNMDA receptorsExcitatory synapses
2003
Modulation of Glutamatergic Transmission by Bergmann Glial Cells in Rat Cerebellum In Situ
Bordey A, Sontheimer H. Modulation of Glutamatergic Transmission by Bergmann Glial Cells in Rat Cerebellum In Situ. Journal Of Neurophysiology 2003, 89: 979-988. PMID: 12574474, DOI: 10.1152/jn.00904.2002.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAmino Acid Transport System X-AGAnimalsAspartic AcidCell CommunicationElectric StimulationExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGlutamic AcidMembrane PotentialsN-MethylaspartateNerve FibersNeurogliaPatch-Clamp TechniquesPurkinje CellsRatsRats, Sprague-DawleyReceptors, GlutamateSodiumSynaptic TransmissionConceptsExcitatory postsynaptic currentsBergmann glial cellsGlial cellsPurkinje cell synapseInward currentsCell synapseGlu transportPurkinje cellsSpontaneous excitatory postsynaptic currentsAbsence of TTXPresynaptic glutamate releaseCerebellar brain slicesSpontaneous EPSC frequencyPatch-clamp recordingsSingle glial cellsIonotropic Glu receptorsParallel fibersEPSC frequencyPresynaptic effectsExcitatory transmissionGlutamate releaseGlutamatergic transmissionPostsynaptic currentsGlu receptorsBrain slices
1997
Electrophysiological Evidence for Multiple Glycinergic Inputs to Neonatal Rat Sympathetic Preganglionic Neurons In Vitro
Krupp J, Bordey A, Feltz P. Electrophysiological Evidence for Multiple Glycinergic Inputs to Neonatal Rat Sympathetic Preganglionic Neurons In Vitro. European Journal Of Neuroscience 1997, 9: 1711-1719. PMID: 9283825, DOI: 10.1111/j.1460-9568.1997.tb01528.x.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic currentsTransverse spinal cord slicesSympathetic preganglionic neuronsSpinal cord slicesPreganglionic neuronsGlycinergic inputsCord slicesNeonatal rat sympathetic preganglionic neuronsGlycinergic inhibitory postsynaptic currentsRat sympathetic preganglionic neuronsExtracellular applicationGlutamate receptor agonistsHigh-frequency burstsDimethylphenylpiperazinium iodidePostsynaptic currentsNeonatal ratsReceptor agonistSynaptic activityElectrophysiological evidenceNeuronsPatchclamp techniqueProximal siteRegular intervalsFrequency of eventsTime patterns
1996
Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices.
Bordey A, Feltz P, Trouslard J. Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices. The Journal Of Physiology 1996, 497: 175-187. PMID: 8951720, PMCID: PMC1160921, DOI: 10.1113/jphysiol.1996.sp021758.Peer-Reviewed Original ResearchConceptsSpontaneous excitatory postsynaptic currentsCentral autonomic areaSympathetic preganglionic neuronesSpinal cord slicesGlutamate-induced currentsAutonomic areasCord slicesTransverse thoracolumbar spinal cord slicesAgonist rank order potencyAction potentialsRat spinal cord slicesWhole-cell patch-clamp techniqueNicotinic acetylcholine receptor agonistExcitatory synaptic activityPresence of tetrodotoxinAcetylcholine receptor agonistExcitatory postsynaptic currentsMembrane current noisePatch-clamp techniqueCurrent-clamp conditionsDetectable current responseRank order potencySEPSC amplitudeVoltage-clamp conditionsStrong inward rectification