2005
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors
Liu X, Wang Q, Haydar TF, Bordey A. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nature Neuroscience 2005, 8: 1179-1187. PMID: 16116450, PMCID: PMC1380263, DOI: 10.1038/nn1522.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBotulinum ToxinsBromodeoxyuridineCadmiumCell CountCell ProliferationChelating AgentsCyclooxygenase InhibitorsDose-Response Relationship, DrugDose-Response Relationship, RadiationDrug InteractionsEgtazic AcidElectric StimulationEnzyme InhibitorsGABA AntagonistsGamma-Aminobutyric AcidGene Expression RegulationGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsImmunohistochemistryIn Vitro TechniquesLateral VentriclesMeclofenamic AcidMembrane PotentialsMiceMice, TransgenicNeuronsNickelPatch-Clamp TechniquesPotassiumSodium Channel BlockersSpider VenomsStem CellsTetrodotoxinConceptsPostnatal subventricular zoneGFAP-expressing cellsSubventricular zoneCell cycleGABAA receptorsStem cellsNeuroblastsProgenitorsGlial fibrillary acidic proteinSVZ cellsGABAA receptor currentsGABAA receptor activationFibrillary acidic proteinReceptor activationCellsProliferationGABA releaseMouse slicesLocal cuesAcidic proteinReceptor currentsSpontaneous depolarizationsGFAPGABAReceptors
2003
GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation
Wang DD, Krueger DD, Bordey A. GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation. The Journal Of Physiology 2003, 550: 785-800. PMID: 12807990, PMCID: PMC2343064, DOI: 10.1113/jphysiol.2003.042572.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBarbituratesBenzodiazepinesCerebral VentriclesDose-Response Relationship, DrugElectrophysiologyGABA AntagonistsGamma-Aminobutyric AcidGlutamate DecarboxylaseIsoenzymesMembrane PotentialsMiceNeostriatumNeuronsPatch-Clamp TechniquesPicrotoxinPotassium ChannelsReceptors, GABA-AStem CellsZincConceptsRostral migratory streamGABAA receptor activationSubventricular zoneNeuronal progenitorsReceptor activationGlutamic acid decarboxylase 67Resting potentialsPostnatal mammalian brainPatch-clamp recordingsSVZ/RMSMouse brain slicesRecorded cellsCell-attached patchesGABA responsesBrain slicesNeurotransmitter GABASubset of progenitorsBenzodiazepine agonistsEmbryonic neuronsAction potentialsMammalian brainMigratory streamGABAInverse agonistSpecific receptors
2002
Carrier‐mediated uptake and release of taurine from Bergmann glia in rat cerebellar slices
Barakat L, Wang D, Bordey A. Carrier‐mediated uptake and release of taurine from Bergmann glia in rat cerebellar slices. The Journal Of Physiology 2002, 541: 753-767. PMID: 12068038, PMCID: PMC2290349, DOI: 10.1113/jphysiol.2001.015834.Peer-Reviewed Original ResearchConceptsRat cerebellar slicesBergmann gliaGuanidinoethyl sulphonateCerebellar slicesTaurine transporterInward currentsWhole-cell patch-clamp recordingsTaurine uptakeGABA receptor blockersTaurine transporter inhibitorRelease of taurinePatch-clamp recordingsDependent taurine transporterOrder of potencyTaurine perfusionReceptor blockersIntracellular taurineIschemic conditionsCarrier-mediated uptakeTaurine effluxOutward currentsTransporter currentsTransporter inhibitorsIntracellular perfusionGlia