2012
miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons
Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A. miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons. PLOS ONE 2012, 7: e38174. PMID: 22693596, PMCID: PMC3364964, DOI: 10.1371/journal.pone.0038174.Peer-Reviewed Original ResearchConceptsOlfactory bulb neuronsSynaptic integrationMiR-132Bulb neuronsSpine densityFrequency of GABAergicGlutamatergic synaptic inputsSubventricular zone neurogenesisMiR-132 overexpressionMiR-132 expressionMicroRNA miR-132Neonatal SVZTransplanted neuronsDendritic complexityNewborn neuronsNeuronal survivalPostnatal neurogenesisSynaptic inputsTransplant therapyDendritic morphogenesisNeuronsVivo electroporationSurvivalSignificant increasePlasticity program
2010
NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network
Platel JC, Dave KA, Gordon V, Lacar B, Rubio ME, Bordey A. NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network. Neuron 2010, 65: 859-872. PMID: 20346761, PMCID: PMC2861893, DOI: 10.1016/j.neuron.2010.03.009.Peer-Reviewed Original ResearchConceptsAdult-born neuronsNMDA receptorsNMDAR activitySynaptic networksNeuroblast survivalGlutamate release machineryAstrocyte-like cellsLoss of neuroblastsNeonatal electroporationSpecialized astrocytesAstrocytic glutamateOlfactory bulbVesicular releaseRelease machineryReceptorsNeuroblastsNeuronsIntercellular mechanismsSurvivalGlutamateNeuroblast apoptosisAstrocytesNeurogenesisNeurotransmittersSVZ