2011
Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion
Feliciano DM, Quon JL, Su T, Taylor MM, Bordey A. Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion. Human Molecular Genetics 2011, 21: 799-810. PMID: 22068588, PMCID: PMC3263992, DOI: 10.1093/hmg/ddr511.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell MovementCerebral CortexDendritesElectroporationFemaleGene DeletionMaleMiceMice, TransgenicNeurogenesisNeurogliaNeuronsOlfactory BulbPeriventricular Nodular HeterotopiaSingle-Cell AnalysisTOR Serine-Threonine KinasesTuberous SclerosisTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsConceptsTuberous sclerosis complexSubventricular zoneBrain lesionsPostnatal subventricular zoneForebrain structuresTsc1 deletionHuman subventricular zoneCortical infiltrationNeurological symptomsNeuropsychiatric symptomsNon-invasive imagingOlfactory lesionsPostnatal neurogenesisTSC patientsPersistent infiltrationTransgenic miceAbnormal circuitsStructural abnormalitiesDendritic treeNeuronal precursorsLesionsEmbryonic neurogenesisNeurogenesisNeuronsMicronodules
2006
Nonsynaptic GABAergic Communication and Postnatal Neurogenesis
Liu X, Bolteus A, Bordey A. Nonsynaptic GABAergic Communication and Postnatal Neurogenesis. Contemporary Neuroscience 2006, 95-104. DOI: 10.1007/978-1-59745-021-8_9.ChaptersFunction of GABASubventricular zonePostnatal neurogenesisNeuronal precursorsNeuron-glial networksSVZ stem cellsStem cellsNeural stem cellsLocal GABAergicNonsynaptic communicationGABAergic systemSynaptic contactsΓ-aminobutyric acidSVZ cellsSVZ precursorsSubependymal zoneGABANeurogenesisCell proliferationCellsEmbryonic cell proliferationGABAergicBrain
2005
Assays for measuring extracellular GABA levels and cell migration rate in acute slices
Bolteus AJ, Garganta C, Bordey A. Assays for measuring extracellular GABA levels and cell migration rate in acute slices. Brain Research 2005, 14: 126-134. PMID: 15721818, DOI: 10.1016/j.brainresprot.2004.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological AssayCell MovementGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidImmunohistochemistryLateral VentriclesMass SpectrometryMembrane Transport ModulatorsMembrane Transport ProteinsMiceMicroscopy, VideoNeurochemistryNeuronsOrgan Culture TechniquesReceptors, GABAStem CellsTelencephalonConceptsRostral migratory streamSubventricular zoneEndogenous GABAGABA levelsGABA receptorsNeuronal precursorsCell migrationLocal GABA levelsExtracellular GABA levelsAcute brain slicesAdult rodent brainPostnatal subventricular zoneFuture therapeutic useNeuronal precursor migrationAcute slicesBrain slicesNeurotransmitter GABASVZ cellsOlfactory bulbRodent brainRMS explantsMigratory streamTherapeutic useNeural precursorsGABA
2004
GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone
Bolteus AJ, Bordey A. GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone. Journal Of Neuroscience 2004, 24: 7623-7631. PMID: 15342728, PMCID: PMC6729616, DOI: 10.1523/jneurosci.1999-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBicucullineBiological TransportBrainCalcium SignalingCell MovementGABA Plasma Membrane Transport ProteinsGABA-A Receptor AgonistsGamma-Aminobutyric AcidMass SpectrometryMembrane Transport ProteinsMiceMicroscopy, VideoNeuronsPatch-Clamp TechniquesPotassiumReceptors, GABA-AStem CellsConceptsAstrocyte-like cellsSubventricular zoneNeuronal precursorsPostnatal subventricular zoneNeuronal precursor migrationCell migrationPrecursor migrationPresence of bicucullineEnhancement of GABAAnterior subventricular zoneInhibition of GABARostral migratory streamAmbient GABA levelsApplication of GABASagittal brain slicesAntagonist bicucullineGABA releaseEndogenous GABAGABA levelsBrain slicesAdult miceGABA transporterMigratory streamGABACell depolarization