2014
GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity
Young SZ, Lafourcade CA, Platel JC, Lin TV, Bordey A. GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity. Frontiers In Cellular Neuroscience 2014, 8: 10. PMID: 24478632, PMCID: PMC3904109, DOI: 10.3389/fncel.2014.00010.Peer-Reviewed Original ResearchSubventricular zoneStriatal neuronsSVZ cellsCalcium increaseCalcium activityNeurogenic subventricular zoneSource of GABAGABAergic striatal neuronsPatch-clamp recordingsPostnatal subventricular zoneNeural progenitor cellsGABAergic neuronsPostnatal neurogenesisGABAA receptorsGABAAR activationClamp recordingsCalcium imagingStriatal activityNeuronsProgenitor cellsGABAAxonsDepolarizationCellsDendrites
2013
Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex
Feliciano DM, Zhang S, Quon JL, Bordey A. Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex. Human Molecular Genetics 2013, 22: 1725-1734. PMID: 23349360, PMCID: PMC3613161, DOI: 10.1093/hmg/ddt018.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor 1aTuberous sclerosis complexShort hairpin RNANewborn neuronsFactor 1ASubventricular zoneSVZ stem cellsNewborn neuron survivalNeurogenic subventricular zoneSingle-cell electroporationTranscriptional activityShRNA expressionHairpin RNAMammalian targetMolecular determinantsNovel microenvironmentNeuron deathNeuron survivalOlfactory lesionsNeonatal miceBrain lesionsStem cellsMouse modelNeuron productionSurvival advantage
2010
GABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels
Young SZ, Platel JC, Nielsen JV, Jensen NA, Bordey A. GABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels. Frontiers In Cellular Neuroscience 2010, 4: 8. PMID: 20422045, PMCID: PMC2857959, DOI: 10.3389/fncel.2010.00008.Peer-Reviewed Original ResearchVoltage-gated calcium channelsT-type voltage-gated calcium channelsAstrocyte-like cellsSubventricular zoneReceptor activationCalcium channelsFunctional voltage-gated calcium channelsChannel activator BayK 8644Glial fibrillary acidic protein promoterHuman glial fibrillary acidic protein promoterNeurogenic subventricular zonePostnatal subventricular zoneAcidic protein promoterAmbient GABABayK 8644Transgenic miceReceptor activityL-typeProtein promoterReceptorsTonicActivationCellsIntracellularMibefradil
2008
GFAP‐GFP neural progenitors are antigenically homogeneous and anchored in their enclosed mosaic niche
Platel J, Gordon V, Heintz T, Bordey A. GFAP‐GFP neural progenitors are antigenically homogeneous and anchored in their enclosed mosaic niche. Glia 2008, 57: 66-78. PMID: 18661547, DOI: 10.1002/glia.20735.Peer-Reviewed Original ResearchConceptsBrain lipid-binding proteinGFAP-expressing cellsSubventricular zoneEGF receptorNeurogenic subventricular zoneGFP-fluorescent cellsHuman GFAP promoterProliferative marker Ki67Neural stem cellsCell typesNeurogenic zonesNG2 cellsPostnatal neurogenesisAcute slicesNeurogenic nicheOlfactory bulbTransgenic miceDifferent cell populationsRostral extensionAntigenic markersGFAP promoterProgenitor markersNeural progenitorsCell populationsCellular mosaic
2007
GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis
Platel JC, Lacar B, Bordey A. GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis. Journal Of Molecular Histology 2007, 38: 303-311. PMID: 17554632, PMCID: PMC2556597, DOI: 10.1007/s10735-007-9103-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSubventricular zoneOlfactory bulb interneuronsGABAergic signalingGlutamate receptorsBulb interneuronsForebrain neurogenesisAMPA/kainate receptorsMetabotropic glutamate receptorsNeurogenic subventricular zoneRole of glutamateHomeostatic controlIonotropic glutamate receptorsEmbryonic cortical developmentSVZ neuroblastsNeurotransmitter GABASVZ cellsCortical developmentKainate receptorsGABA transporter subtypesNeurotransmitter glutamateGABA clearanceGABATransporter subtypesReceptorsInterneurons