2015
The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell
Platel JC, Bordey A. The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell. Neuroscience 2015, 323: 20-28. PMID: 26546469, PMCID: PMC4821790, DOI: 10.1016/j.neuroscience.2015.10.053.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVentricular-subventricular zoneNeural progenitor cellsPro-neurogenic roleHippocampal dentate gyrusNeural stem cellsSubgranular zoneNewborn neuronsNeurogenic propertiesDentate gyrusNew neuronsLateral ventricleAdult brainMature astrocytesTranscription factor expressionNeurogenic fateNeurophysiological characteristicsFactor expressionAstrocytesBlood vesselsProgenitor cellsMetabolic couplingSurvival cuesNeuronsStem cellsCells
2014
GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity
Young SZ, Lafourcade CA, Platel JC, Lin TV, Bordey A. GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity. Frontiers In Cellular Neuroscience 2014, 8: 10. PMID: 24478632, PMCID: PMC3904109, DOI: 10.3389/fncel.2014.00010.Peer-Reviewed Original ResearchSubventricular zoneStriatal neuronsSVZ cellsCalcium increaseCalcium activityNeurogenic subventricular zoneSource of GABAGABAergic striatal neuronsPatch-clamp recordingsPostnatal subventricular zoneNeural progenitor cellsGABAergic neuronsPostnatal neurogenesisGABAA receptorsGABAAR activationClamp recordingsCalcium imagingStriatal activityNeuronsProgenitor cellsGABAAxonsDepolarizationCellsDendrites
2013
Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons
Lafourcade CA, Lin TV, Feliciano DM, Zhang L, Hsieh LS, Bordey A. Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons. Journal Of Neuroscience 2013, 33: 2419-2431. PMID: 23392671, PMCID: PMC3711634, DOI: 10.1523/jneurosci.1840-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell DifferentiationCell EnlargementCell Line, TumorCell MovementCerebral VentriclesDendritesElectroporationFemaleHypertrophyMaleMiceMonomeric GTP-Binding ProteinsNeural Stem CellsNeurogenesisNeuronsNeuropeptidesOlfactory BulbRas Homolog Enriched in Brain ProteinSirolimusStem CellsTOR Serine-Threonine KinasesConceptsNeural progenitor cellsWild-type miceOlfactory bulbMTOR activitySynaptic inputsEctopic neuronal differentiationSubventricular zone neural progenitor cellsActive ras homologNeuronal differentiationGABAergic synaptic inputsTsc1 mutant miceSubventricular zone progenitorsDendritic complexityNewborn neuronsTuberous sclerosisOlig2 cellsHyperactive mTORHeterozygote miceCircuit formationAction potentialsNeuronal morphologyNewborn cellsMutant miceEctopic cellsMammalian target
2012
Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone
Lacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone. Journal Of Neuroscience 2012, 32: 16435-16448. PMID: 23152626, PMCID: PMC3520061, DOI: 10.1523/jneurosci.1457-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornAstrocytesCalcium SignalingCapillariesCerebral VentriclesCerebrovascular CirculationElectric StimulationElectroporationFemaleFluorescent Antibody TechniqueImage Processing, Computer-AssistedLaser-Doppler FlowmetryMaleMiceMuscle TonusMuscle, Smooth, VascularNeural Stem CellsPericytesVasoconstrictionVasodilationConceptsNeural progenitor cellsSubventricular zoneB cellsBlood flowSVZ cellsPurinergic receptorsPostnatal subventricular zoneVascular responsesCapillary constrictionTransgenic miceElectrical stimulationCalcium increaseBlood flow increasesLaser Doppler flowmetryCapillary blood flowAstrocyte-like cellsReceptor agonist UTPNeonatal electroporationNeurometabolic couplingIntraventricular injectionVasodilating factorsAcute slicesYoung miceDoppler flowmetryHemodynamic responsePreparation of acute subventricular zone slices for calcium imaging.
Lacar B, Young SZ, Platel JC, Bordey A. Preparation of acute subventricular zone slices for calcium imaging. Journal Of Visualized Experiments 2012, e4071. PMID: 23023088, PMCID: PMC3490239, DOI: 10.3791/4071.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCell typesSVZ cellsProgenitor cellsNeurogenic zonesSubventricular zoneFluo-4 AM dyeNeural progenitor cellsIntermediate progenitor cellsExtracellular signalsDiffusible signalsIntercellular signalingSVZ cell typesTime-lapse moviesCalcium indicator dyeCalcium activityIndividual cellsRostral-caudal axisNeuroblast migrationThree-dimensional arrangementAdult hippocampal subgranular zonePostnatal brainAdhesion moleculesHippocampal subgranular zoneMature astrocytesNeuroblastsS Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone
Lacar B, Herman P, Hartman NW, Hyder F, Bordey A. S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone. PLOS ONE 2012, 7: e31960. PMID: 22359646, PMCID: PMC3281100, DOI: 10.1371/journal.pone.0031960.Peer-Reviewed Original ResearchConceptsSubventricular zoneBlood flowNeural progenitor cellsAcute brain slice preparationGrowth factor injectionsProgenitor cellsReceptor agonist UIncreased blood flowBrain slice preparationSVZ cell proliferationCell proliferationLaser Doppler flowmetryLocal blood flowLocal hemodynamic responsesBasic fibroblast growth factorPostnatal subventricular zoneFibroblast growth factorAgonist UFactor injectionsVentricular injectionNeurovascular couplingAcute increaseSlice preparationDoppler flowmetryHemodynamic response
2011
Gap junction‐mediated calcium waves define communication networks among murine postnatal neural progenitor cells
Lacar B, Young SZ, Platel J, Bordey A. Gap junction‐mediated calcium waves define communication networks among murine postnatal neural progenitor cells. European Journal Of Neuroscience 2011, 34: 1895-1905. PMID: 22098557, PMCID: PMC3237798, DOI: 10.1111/j.1460-9568.2011.07901.x.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsNeurogenic nicheB2 cellsBlood vesselsCalcium wavesPurinergic receptor blockerProgenitor cellsPostnatal neurogenic nichesFunctional couplingPostnatal neural progenitor cellsGap junction blockersGap junction protein connexin 43Neonatal electroporationNiche astrocytesReceptor blockersProtein connexin 43Intercellular calcium wavesSubventricular zoneCells persistJunction blockersB1 cellsB cellsDye couplingDistinct entityConnexin 43