SR 140333, a Novel, Selective, and Potent Nonpeptide Antagonist of the NK1 Tachykinin Receptor: Characterization on the U373MG Cell Line
Oury‐Donat F, Lefevre IA, Thurneyssen O, Gauthier T, Bordey A, Feltz P, Emonds‐Alt X, Le Fur G, Soubrie P. SR 140333, a Novel, Selective, and Potent Nonpeptide Antagonist of the NK1 Tachykinin Receptor: Characterization on the U373MG Cell Line. Journal Of Neurochemistry 1994, 62: 1399-1407. PMID: 7510780, DOI: 10.1046/j.1471-4159.1994.62041399.x.Peer-Reviewed Original ResearchMeSH KeywordsAstrocytomaBinding, CompetitiveCalciumElectric ConductivityGenes, fosHumansInositol PhosphatesIodine RadioisotopesNeurokinin-1 Receptor AntagonistsPeptide FragmentsPiperidinesPotassiumPyrrolidonecarboxylic AcidQuinuclidinesReceptors, Neurokinin-1StereoisomerismSubstance PSuccinimidesTaurineTranscription, GeneticTumor Cells, CulturedConceptsSR 140333Substance PNK1 tachykinin receptor antagonistNK1 receptor activationHunter substance PNK1-selective agonistTachykinin receptor antagonistsInositol monophosphate formationNK1 tachykinin receptorsPotent nonpeptide antagonistHuman astrocytoma cell lineCell linesAstrocytoma cell linesPatch-clamp experimentsReceptor antagonistFormation of inositolTachykinin receptorsNK1 agonistU373MG cell linesCalcium mobilizationNonpeptide antagonistsRadioligand bindingReceptor activationOutward currentsMonophosphate formation