2016
Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration
Lin TV, Hsieh L, Kimura T, Malone TJ, Bordey A. Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 11330-11335. PMID: 27647922, PMCID: PMC5056085, DOI: 10.1073/pnas.1605740113.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCell Cycle ProteinsDendritic SpinesEukaryotic Initiation FactorsExcitatory Postsynaptic PotentialsGene Knockdown TechniquesGreen Fluorescent ProteinsMatrix Attachment Region Binding ProteinsMechanistic Target of Rapamycin Complex 1MiceNeurogliaNeuronsPhosphoproteinsProtein BiosynthesisRas Homolog Enriched in Brain ProteinRNA CapsRNA, Small InterferingSignal TransductionTOR Serine-Threonine KinasesTranscription FactorsConceptsBrain cytoarchitectureUpper layer cortical neuronsHyperactive mammalian targetDendritic hypertrophyCortical neuronsCap-dependent translationEctopic placementRadial gliaMammalian targetLate corticogenesisTranslational repressor eukaryotic initiation factor 4EEukaryotic initiation factor 4ENeurodevelopmental disordersProtein 1Rapamycin complex 1Molecular hallmarksInitiation factor 4EMechanisms downstreamCytoarchitectureMolecular identityMisplacementActive mutantHypertrophyGliaOveractivation
2008
The astrocyte odyssey
Wang DD, Bordey A. The astrocyte odyssey. Progress In Neurobiology 2008, 86: 342-367. PMID: 18948166, PMCID: PMC2613184, DOI: 10.1016/j.pneurobio.2008.09.015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdult neurogenic zonesFunction of astrocytesAstrocytic calcium wavesPopulation of astrocytesDifferent molecular identitiesNeural stem cellsGlutamate releaseNeurogenic zonesNeurogenic nicheNeuronal activityNervous systemStem cell characteristicsAstrocytesNeuronsCalcium wavesVivo roleSupport cellsStem cellsEqual numberCellsDiverse populationsMolecular identityCell characteristicsPioneer discoveriesCentral player