2016
Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice
Mahoney C, Feliciano DM, Bordey A, Hartman NW. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neuroscience Letters 2016, 614: 112-118. PMID: 26812181, DOI: 10.1016/j.neulet.2015.12.042.Peer-Reviewed Original ResearchConceptsNeural stem cellsSubventricular zoneNeonatal subventricular zoneWeek old miceTuberous sclerosis complexStem cellsNewborn neuroblastsYoung miceOld miceProgressive lossYoung adultsRapamycin complex 1Mechanistic targetRecent evidenceProliferative cellsMiceHyperactive mTORC1Terminal differentiationCellsMTORC1 activationProliferationActivationMTORC1NeurogenesisHyperactivity
2010
GABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels
Young SZ, Platel JC, Nielsen JV, Jensen NA, Bordey A. GABAA Increases Calcium in Subventricular Zone Astrocyte-Like Cells Through L- and T-Type Voltage-Gated Calcium Channels. Frontiers In Cellular Neuroscience 2010, 4: 8. PMID: 20422045, PMCID: PMC2857959, DOI: 10.3389/fncel.2010.00008.Peer-Reviewed Original ResearchVoltage-gated calcium channelsT-type voltage-gated calcium channelsAstrocyte-like cellsSubventricular zoneReceptor activationCalcium channelsFunctional voltage-gated calcium channelsChannel activator BayK 8644Glial fibrillary acidic protein promoterHuman glial fibrillary acidic protein promoterNeurogenic subventricular zonePostnatal subventricular zoneAcidic protein promoterAmbient GABABayK 8644Transgenic miceReceptor activityL-typeProtein promoterReceptorsTonicActivationCellsIntracellularMibefradil