2011
WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters*
Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters*. Journal Of Biological Chemistry 2011, 286: 30171-30180. PMID: 21733846, PMCID: PMC3191056, DOI: 10.1074/jbc.m111.222893.Peer-Reviewed Original ResearchConceptsCation-chloride cotransportersSerine-threonine phosphorylationKinase-dependent mannerMammalian brainCell volume regulationSer-383Protein complexesRegulatory cascadeCotransporter regulationXenopus laevis oocytesNovel regulatorWNK2KinaseLaevis oocytesVolume regulationCl accumulationRecognition sitesWNKIntracellular concentrationRegulationSPAKAdult brainThalamic relay cellsThiazide-sensitive NCCMass spectrometry studies
2005
WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability
Kahle KT, Rinehart J, de los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP. WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 16783-16788. PMID: 16275911, PMCID: PMC1283843, DOI: 10.1073/pnas.0508307102.Peer-Reviewed Original ResearchConceptsReticular activating systemCl- influxAltered phosphorylationCerebral cortexResponsive neuronsGABA neurotransmissionNeuronal excitabilityK-Cl cotransporterOpposite effectActivating systemCotransporter NKCC1Intracellular ClCl- effluxNKCC1Surface expressionKCC2Cell volumeExcitabilityNeuronsDownstream targetsWNK3Sensitive kinasesXenopus oocytesIntracellular volumeIon cotransporters