2000
SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder
Bremner J, Innis R, White T, Fujita M, Silbersweig D, Goddard A, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney D. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 2000, 47: 96-106. PMID: 10664825, DOI: 10.1016/s0006-3223(99)00188-2.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingBenzodiazepine receptor functionPanic disorder patientsBenzodiazepine receptorsPanic disorderReceptor bindingDisorder patientsPanic attacksReceptor functionPrefrontal cortexSingle photon emissionStatistical parametric mappingGABAergic transmissionHealthy controlsFrontal cortexLeft hippocampusAnimal modelsComparison subjectsPatientsChronic stressPanic anxietyTomography imagingParametric mappingCortexSpecific decrease
1997
Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects
Price L, Cappiello A, Malison R, McDougle C, Pelton G, Schöllnhammer G, Heninger G. Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects. Neuropsychopharmacology 1997, 17: 246-257. PMID: 9326749, DOI: 10.1016/s0893-133x(97)00049-3.Peer-Reviewed Original ResearchConceptsDepressed patientsReceptor functionHealthy control subjectsUnipolar depressed patientsAntiglucocorticoid treatmentAntidepressant actionGlucocorticoid modulationPreclinical findingsAdrenal axisControl subjectsAntidepressant activityClinical studiesTest doseHealthy subjectsReceptor sensitivityIpsapironeCortisol biosynthesisKetoconazoleDepressionPatientsBehavioral responsesSubjectsGlucocorticoidsAgonistsNeuroendocrine