The use of pindolol with fluoxetine in the treatment of major depression: final results from a double-blind, placebo-controlled trial
Berman R, Anand A, Cappiello A, Miller H, Hu X, Oren D, Charney D. The use of pindolol with fluoxetine in the treatment of major depression: final results from a double-blind, placebo-controlled trial. Biological Psychiatry 1999, 45: 1170-1177. PMID: 10331109, DOI: 10.1016/s0006-3223(98)00383-7.Peer-Reviewed Original ResearchConceptsPlacebo groupClinical responseMore weeksDrug-free outpatientsEfficacy of pindololPartial remission rateUse of pindololPlacebo-controlled trialDouble-blind mannerMajor depressive episodeSingle-blind mannerPindolol groupPindolol treatmentPartial remissionRemission rateBlood pressureReuptake inhibitorsStudy endPatient populationDepressive episodeDepressed patientsMajor depressionRecurrent depressionSide effectsControl groupEffect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder
Anand A, Darnell A, Miller H, Berman R, Cappiello A, Oren D, Woods S, Charney D. Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder. Biological Psychiatry 1999, 45: 972-978. PMID: 10386179, DOI: 10.1016/s0006-3223(98)00293-5.Peer-Reviewed Original ResearchConceptsLong-term remissionBipolar disorderCatecholamine depletionLithium therapyHypomanic symptomsLong-term lithium therapyRandomized double-blind mannerDSM-IV bipolar disorderDouble-blind mannerMechanism of preventionTransient relapseManic relapsePlacebo administrationSerum levelsCatecholamine systemsHomovanillic acidRemissionRelapseDisordersTherapyTest sessionsSymptomsSubjectsSignificant changesMood indices