2024
Accessing breast cancer care in a protracted conflict: Qualitative exploration of the perspectives of women with breast cancer in northwest Syria
Marzouk M, Hamze M, Debel J, Alshemali A, Alameen B, Bakkour M, Galal B, Chagpar A, Atassi B, Khoshnood K, Abbara A. Accessing breast cancer care in a protracted conflict: Qualitative exploration of the perspectives of women with breast cancer in northwest Syria. Social Science & Medicine 2024, 361: 117364. PMID: 39357306, DOI: 10.1016/j.socscimed.2024.117364.Peer-Reviewed Original ResearchSyrian American Medical SocietyBreast cancer carePerspective of womenSemi-structured interviewsCancer careExperiences of accessing careBreast cancerAmerican Medical SocietyBreast cancer diagnosisAvailability of radiotherapyThematic saturationAccessing careHealthcare staffOncology careNorthwest SyriaPeer supportSocial supportThematic analysisClinical careFinancial strainMultiple intersectional challengesCancer diagnosisCareAccess diagnosisHospital records
2023
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trialsASO Visual Abstract: Does Preoperative MRI Reduce Positive Margins After Breast Conserving Surgery?
Cairns A, Chagpar A, Dupont E, Levine E, Gass J, Chiba A, Ollila D, Howard-McNatt M. ASO Visual Abstract: Does Preoperative MRI Reduce Positive Margins After Breast Conserving Surgery? Annals Of Surgical Oncology 2023, 30: 6059-6060. DOI: 10.1245/s10434-023-14002-4.Peer-Reviewed Original ResearchDoes Preoperative MRI Reduce Positive Margins after Breast-Conserving Surgery?
Cairns A, Chagpar A, Dupont E, Levine E, Gass J, Chiba A, Ollila D, Howard-McNatt M. Does Preoperative MRI Reduce Positive Margins after Breast-Conserving Surgery? Annals Of Surgical Oncology 2023, 30: 6053-6058. PMID: 37505353, DOI: 10.1245/s10434-023-13884-8.Peer-Reviewed Original ResearchConceptsPreoperative magnetic resonance imagingMagnetic resonance imagingExtensive intraductal componentMargin statusPositive marginsTumor sizeTumor factorsMedian tumor sizeBreast conserving surgeryBreast cancer managementInvasive lobular histologyNeoadjuvant chemotherapyLobular histologyIntraductal componentMedian ageMulticenter trialPatient agePalpable tumorsPatient factorsShave marginsNegative marginsResultsA totalAssociated FactorsBreast cancerUS CentersChange
Chagpar A. Change. The American Journal Of Surgery 2023, 226: 756-759. PMID: 37328327, DOI: 10.1016/j.amjsurg.2023.06.009.Peer-Reviewed Original ResearchThe impact of virtual negotiation training for female faculty
Chagpar A. The impact of virtual negotiation training for female faculty. Global Surgical Education - Journal Of The Association For Surgical Education 2023, 2: 20. PMID: 38013874, PMCID: PMC9838252, DOI: 10.1007/s44186-022-00098-x.Peer-Reviewed Original Research
2022
Randomized trial of diet and exercise on chemotherapy completion in women with breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) study.
Sanft T, Harrigan M, Cartmel B, Li F, Zupa M, McGowan C, Ferrucci L, Puklin L, Nguyen T, Tanasijevic A, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf M, Chagpar A, Silber A, Ligibel J, Irwin M. Randomized trial of diet and exercise on chemotherapy completion in women with breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) study. Journal Of Clinical Oncology 2022, 40: 12007-12007. DOI: 10.1200/jco.2022.40.16_suppl.12007.Peer-Reviewed Original ResearchRelative dose intensityHigh relative dose intensityBreast cancerDose-response effectPhysical activityPA interventionsNeoadjuvant chemotherapyChemotherapy completionDiet qualityStage I breast cancerEndocrine therapy adherenceTrial of dietDifferent chemotherapy regimensI breast cancerBody mass indexPatient-reported outcomesHealthy Eating IndexBetter diet qualityHigh physical activityMore physical activityElectronic medical recordsChi-square testUC participantsChemotherapy regimensSecondary endpointsDoes perceived stigma or shame affect stage of presentation in Iraqi Kurdish women diagnosed with breast cancer?
Chagpar A, Qader S, Baqri M, Khoshnood K, Ahmed H. Does perceived stigma or shame affect stage of presentation in Iraqi Kurdish women diagnosed with breast cancer? Journal Of Clinical Oncology 2022, 40: e18680-e18680. DOI: 10.1200/jco.2022.40.16_suppl.e18680.Peer-Reviewed Original ResearchStage 1 diseaseBreast cancerStage diseaseStage 1 breast cancerHigher stage diseaseLate-stage diseaseStage of presentationCancer Stigma ScaleMonthly household incomeBCSS scoreMost patientsCancer patientsBreast centerPatientsStigma ScaleFeelings of shameFeelings of stigmaCancerDiseaseWomenPossible scoreMarital statusIraqi womenDiagnosisStage 1Are patients with alcohol-related cancers (ARCs) more likely to quit drinking than the general population? Results of a national population-based survey.
Ishani K, Chagpar A. Are patients with alcohol-related cancers (ARCs) more likely to quit drinking than the general population? Results of a national population-based survey. Journal Of Clinical Oncology 2022, 40: e18716-e18716. DOI: 10.1200/jco.2022.40.16_suppl.e18716.Peer-Reviewed Original ResearchAlcohol-related cancersGeneral populationAnnual household incomeNational Health Interview Survey (NHIS) datasetHeavy drinkersNational population-based surveyThird of patientsRisk of recurrencePopulation-based surveyCurrent heavy drinkersVariety of cancersProportion of peopleIndependent predictorsPrivate health insuranceHigh school educationPatientsSociodemographic factorsMultivariate analysisPublic insuranceHousehold incomeCancerHealth insuranceDrinkersLower ratesDrinkingClinical outcomes and immune markers by race in a phase I/II clinical trial of durvalumab concomitant with neoadjuvant chemotherapy in early-stage TNBC.
Foldi J, Kahn A, Silber A, Qing T, Reisenbichler E, Fischbach N, Persico J, Adelson K, Katoch A, Chagpar A, Park T, Blanchard A, Blenman K, Rimm D, Pusztai L. Clinical outcomes and immune markers by race in a phase I/II clinical trial of durvalumab concomitant with neoadjuvant chemotherapy in early-stage TNBC. Journal Of Clinical Oncology 2022, 40: 516-516. DOI: 10.1200/jco.2022.40.16_suppl.516.Peer-Reviewed Original ResearchImmune-related adverse eventsTriple-negative breast cancerMultivariate logistic regression analysisPD-L1 statusLogistic regression analysisAA raceOverall survivalPathologic responseClinical trialsBreast cancerEarly-stage triple-negative breast cancerIncidence of irAEsPhase I/II trialPathologic complete response rateSignificant associationPhase I/II clinical trialsBaseline body mass indexSafety of immunotherapyWeekly nab-paclitaxelCharlson Comorbidity IndexComplete response ratePrimary efficacy endpointPD-L1 expressionBody mass indexBreast cancer recurrenceThe Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients
Trant A, Chagpar A, Wei W, Neumeister V, Rimm D, Stavris K, Lurie B, Frederick C, Andrejeva L, Raghu M, Killelea B, Horowitz N, Lannin D, Knill-Selby E, Sturrock T, Hofstatter E. The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients. Integrative Cancer Therapies 2022, 21: 15347354221137290. PMID: 36444764, PMCID: PMC9716631, DOI: 10.1177/15347354221137290.Peer-Reviewed Original ResearchConceptsTumor volumeBlack cohoshSitu patientsDuctal carcinomaAnti-inflammatory effectsTumor cellular proliferationBreast cancer treatmentCellular proliferationWilcoxon signed-rank testDCIS patientsAdverse eventsEligible subjectsWindow trialsCore biopsyInvasive diseaseKi67 expressionSigned-rank testBreast cancerGrade 3Hormone changesPatientsQuantitative immunofluorescenceBC extractSignificant toxicityCancer treatment
2021
Factors Affecting Telehealth Availability Among Breast Centers During the Pandemic
Doernberg H, Hsiang W, Marks V, Pak I, Kim D, Galal B, Umer W, Haleem A, Chagpar A. Factors Affecting Telehealth Availability Among Breast Centers During the Pandemic. Journal Of The American College Of Surgeons 2021, 233: s35. DOI: 10.1016/j.jamcollsurg.2021.07.047.Peer-Reviewed Original ResearchHPV vaccination and factors influencing vaccine uptake among people of Indian ancestry living in the United States.
Ratnasamy P, Chagpar A. HPV vaccination and factors influencing vaccine uptake among people of Indian ancestry living in the United States. Journal Of Clinical Oncology 2021, 39: 126-126. DOI: 10.1200/jco.2020.39.28_suppl.126.Peer-Reviewed Original ResearchNational Health Interview SurveyHPV vaccinationHPV vaccine initiationHPV vaccine uptakeGeneral US populationVaccination ratesVaccine uptakeUS populationVaccine initiationCivilian non-institutionalized US populationLow HPV vaccination ratesNon-institutionalized US populationHPV vaccine availabilityVaccine series completionCervical cancer deathsHPV vaccination ratesHigh vaccination ratesHealth Interview SurveyPublic health measuresIndian ancestryVaccine seriesCancer deathInsurance statusRacial groupsVaccine hesitancyMilestone Studies in Breast Cancer Surgery
Chagpar A. Milestone Studies in Breast Cancer Surgery. 2021, 9-17. DOI: 10.1007/978-3-030-73147-2_2.Peer-Reviewed Original ResearchBreast cancer surgeryCancer surgerySentinel node biopsyBreast-conserving surgeryPostoperative cosmetic outcomeBreast cancer managementAxillary dissectionNode biopsyRadical mastectomyLandmark trialsSurgical managementSurgical interventionCosmetic outcomeMargin clearanceBreast cancerCancer managementSurgeryRadiation oncologyMultidisciplinary approachOngoing studiesMilestone studyNumber of advancesMastectomyMorbidityAxillaASO Visual Abstract: Debate: Postmastectomy Radiation Therapy in T1/2N1 Disease
Chagpar A. ASO Visual Abstract: Debate: Postmastectomy Radiation Therapy in T1/2N1 Disease. Annals Of Surgical Oncology 2021, 28: 648-648. DOI: 10.1245/s10434-021-10689-5.Peer-Reviewed Original ResearchASO Visual Abstract: Assessing Interobserver Variability of Cosmetic Outcome Assessment in Breast Cancer Patients Undergoing Breast Conservation Surgery
Chagpar A, Berger E, Alperovich M, Zanieski G, Avraham T, Lannin D. ASO Visual Abstract: Assessing Interobserver Variability of Cosmetic Outcome Assessment in Breast Cancer Patients Undergoing Breast Conservation Surgery. Annals Of Surgical Oncology 2021, 28: 632-632. DOI: 10.1245/s10434-021-10584-z.Peer-Reviewed Original ResearchImpact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.
Dieli-Conwright C, Harrigan M, Cartmel B, Chagpar A, Bai Y, Rimm D, Pusztai L, Lu L, Sanft T, Irwin M. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Journal Of Clinical Oncology 2021, 39: e12501-e12501. DOI: 10.1200/jco.2021.39.15_suppl.e12501.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionSerum insulin levelsCancer survivorsLoss interventionPercent body fatSerum levelsSerum biomarkersTissue biomarkersBody compositionMonth 6Insulin levelsBreast tissueBreast cancerInsulin receptorBody fatStage I breast cancerBreast tissue levelsI breast cancerWeight loss trialBreast tissue markersLevels of CD163Breast tissue biopsiesUsual careLifestyle interventionHow did the COVID crisis affect use of neoadjuvant therapy for patients with breast cancer?
Chagpar A, Lannin D, Mougalian S, Berger E, Gross C, Horowitz N, Sanft T, DiGiovanna M, Golshan M, Pusztai L. How did the COVID crisis affect use of neoadjuvant therapy for patients with breast cancer? Journal Of Clinical Oncology 2021, 39: e18708-e18708. DOI: 10.1200/jco.2021.39.15_suppl.e18708.Peer-Reviewed Original ResearchUse of NTNeoadjuvant therapyEarly pandemic periodBreast cancerNon-metastatic breast cancerPractice settingsEarly pandemicFlatiron Health databaseNeoadjuvant endocrine therapyTechnology-enabled abstractionSame period one yearSimilar clinicopathologic featuresLongitudinal electronic health recordsPeriod one yearElectronic health recordsTNBC subsetEndocrine therapyPatient ageTN patientsClinicopathologic featuresContemporary cohortClinical stageCancer clinicCancer managementHigh risk
2020
Is there an association between air pollution levels and lung cancer incidence?
Patel S, Chagpar A. Is there an association between air pollution levels and lung cancer incidence? Journal Of Clinical Oncology 2020, 38: e13584-e13584. DOI: 10.1200/jco.2020.38.15_suppl.e13584.Peer-Reviewed Original ResearchLung cancer incidence ratesLung cancer incidenceCancer incidence ratesMedian PMCancer incidenceIncidence rateProportion of smokersCountry-specific dataAir pollution levelsGlobal Cancer ObservatoryWorld Health OrganizationMedian ageRespiratory illnessTobacco useOlder populationSPSS version 26.0Health OrganizationVersion 26.0AgeLinear regression modelsIncidenceMultiple linear regression modelRegression modelsProportion of populationAssociation
2019
Factors associated with breast cancer mortality-per-incident case in low-to-middle income countries (LMICs).
Chagpar A, Coccia M. Factors associated with breast cancer mortality-per-incident case in low-to-middle income countries (LMICs). Journal Of Clinical Oncology 2019, 37: 1566-1566. DOI: 10.1200/jco.2019.37.15_suppl.1566.Peer-Reviewed Original Research