2014
Lipid-Dependent Bimodal MCL1 Membrane Activity
Landeta O, Valero J, Flores-Romero H, Bustillo-Zabalbeitia I, Landajuela A, Garcia-Porras M, Terrones O, Basañez G. Lipid-Dependent Bimodal MCL1 Membrane Activity. ACS Chemical Biology 2014, 9: 2852-2863. PMID: 25314294, DOI: 10.1021/cb500592e.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBcl-2-Associated X ProteinBH3 Interacting Domain Death Agonist ProteinCardiolipinsCholesterolFibroblastsGene ExpressionHeLa CellsHumansLiposomesMembrane LipidsMembrane Potential, MitochondrialMiceMitochondriaModels, MolecularMolecular Sequence DataMutagenesis, Site-DirectedMyeloid Cell Leukemia Sequence 1 ProteinPhosphatidylinositolsProtein Structure, TertiaryProto-Oncogene Proteins c-bcl-2Recombinant ProteinsSequence AlignmentConceptsPore-forming activityProtein functionConformational changesMitochondrial membrane lipidsLipid membrane environmentSite-directed mutagenesisProfound conformational changesNovel mechanistic insightsMembrane integrationCanonical BH3Homology regionMembrane environmentMembrane permeabilizationMitochondrial lipidsMinimal domainMembrane lipidsMitochondrial levelGroove interactionsProapoptotic partnersMcl1 activityMechanistic insightsMembrane activityModel membranesFluorescence spectroscopic analysisPermeabilization
2010
Role of mitochondrial lipids in proapoptotic BAK function: mechanistic insights from in vitro reconstituted systems
Landeta O, Landajuela A, Basañez G. Role of mitochondrial lipids in proapoptotic BAK function: mechanistic insights from in vitro reconstituted systems. Chemistry And Physics Of Lipids 2010, 163: s10. DOI: 10.1016/j.chemphyslip.2010.05.033.Peer-Reviewed Original Research