2005
Electrocardiographic Changes in Children and Adolescents Treated With Ziprasidone: A Prospective Study
BLAIR J, SCAHILL L, STATE M, MARTIN A. Electrocardiographic Changes in Children and Adolescents Treated With Ziprasidone: A Prospective Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2005, 44: 73-79. PMID: 15608546, DOI: 10.1097/01.chi.0000145372.61239.bb.Peer-Reviewed Original ResearchConceptsQTc intervalClose electrocardiographic monitoringMean QTc prolongationQTc-prolonging agentsOpen-label trialLonger QTc intervalsCurrent treatment standardsQRS complex widthZiprasidone dosePediatric outpatientsQTc prolongationElectrocardiographic changesElectrocardiographic monitoringProspective studyMean ageSafety profilePeak QTcHeart rateHigh dosesZiprasidoneTreatment standardsDoseDosesPreliminary findingsProlongation
2004
Electrocardiographic safety profile and monitoring guidelines in pediatric psychopharmacology
Blair J, Taggart B, Martin A. Electrocardiographic safety profile and monitoring guidelines in pediatric psychopharmacology. Journal Of Neural Transmission 2004, 111: 791-815. PMID: 15205999, DOI: 10.1007/s00702-004-0153-8.Peer-Reviewed Original ResearchConceptsPediatric psychopharmacologyQTc prolongationQTc intervalNumber of medicationsTricyclic antidepressant desipramineAdult patientsYounger patientsElectrocardiographic monitoringAlpha agonistsSafety profileDeadly arrhythmiasAntidepressant desipramineSudden deathAdverse effectsMost reportsPatientsPsychopharmacologyProlongationCurrent knowledgeChildrenReportGuidelinesAntipsychoticsMedicationsTorsades