Pharmacotherapy of Early-Onset Depression Update and New Directions
Martin A, Kaufman J, Charney D. Pharmacotherapy of Early-Onset Depression Update and New Directions. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 135-157. PMID: 10674194, DOI: 10.1016/s1056-4993(18)30139-1.Peer-Reviewed Original ResearchConceptsEarly-onset depressionDepressive disorderSafety dataLong-term exposureBrain-derived neurotrophic factor levelsLong-term safety dataEarly-onset depressive disordersAvailable antidepressant agentsRigid treatment guidelinesUseful treatment interventionsNeurotrophic factor levelsLong-term followShort-term efficacyShort-term efficacy dataAtrophic brain changesHigh recurrence ratePsychopharmacology Algorithm ProjectRoutine clinical practiceAlternative treatment strategiesYears of ageShort-term trialsPaucity of dataRisk-benefit analysisLong-term useAntidepressant medication