2006
Effects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism
Anderson GM, Scahill L, McCracken JT, McDougle CJ, Aman MG, Tierney E, Arnold LE, Martin A, Katsovich L, Posey DJ, Shah B, Vitiello B. Effects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism. Biological Psychiatry 2006, 61: 545-550. PMID: 16730335, DOI: 10.1016/j.biopsych.2006.02.032.Peer-Reviewed Original ResearchConceptsRisperidone-induced increasesLong-term risperidone treatmentProlactin levelsRisperidone treatmentSerum prolactinOpen-label followWeeks of risperidoneBaseline prolactin levelsEffects of ShortPlacebo groupProlactin elevationReceptor polymorphismsWeek 8Baseline levelsMean increaseProlactinRisperidoneSerum samplesAdverse effectsPlaceboChildrenTreatmentMonthsDRD2 allelesAdolescents
2004
Electrocardiographic safety profile and monitoring guidelines in pediatric psychopharmacology
Blair J, Taggart B, Martin A. Electrocardiographic safety profile and monitoring guidelines in pediatric psychopharmacology. Journal Of Neural Transmission 2004, 111: 791-815. PMID: 15205999, DOI: 10.1007/s00702-004-0153-8.Peer-Reviewed Original ResearchConceptsPediatric psychopharmacologyQTc prolongationQTc intervalNumber of medicationsTricyclic antidepressant desipramineAdult patientsYounger patientsElectrocardiographic monitoringAlpha agonistsSafety profileDeadly arrhythmiasAntidepressant desipramineSudden deathAdverse effectsMost reportsPatientsPsychopharmacologyProlongationCurrent knowledgeChildrenReportGuidelinesAntipsychoticsMedicationsTorsades