Spontaneous translocation of a human enterococcal gut pathobiont drives systemic autoimmunity
Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Barbieri A, Jain D, Goodman A, Kriegel M. Spontaneous translocation of a human enterococcal gut pathobiont drives systemic autoimmunity. The Journal Of Immunology 2018, 200: 162.10-162.10. DOI: 10.4049/jimmunol.200.supp.162.10.Peer-Reviewed Original ResearchHost-microbiota interactionsOral vancomycin treatmentInduction of autoantibodiesPlasmacytoid dendritic cellsMesenteric lymph nodesPathogenesis of autoimmunityE. gallinarumAutoimmune hepatitisTfh cellsLupus patientsOrgan manifestationsPathogenic autoantibodiesDendritic cellsLymph nodesCytokines IFNGut barrierVancomycin treatmentC57BL/6 animalsSystemic autoimmunityInduction of moleculesLiver tissueAutoimmunityAhR pathwayBarrier functionMucus layerTranslocation of a gut pathobiont drives autoimmunity in mice and humans
Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa FRC, Tiniakou E, Greiling T, Ruff W, Barbieri A, Kriegel C, Mehta SS, Knight JR, Jain D, Goodman AL, Kriegel MA. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 2018, 359: 1156-1161. PMID: 29590047, PMCID: PMC5959731, DOI: 10.1126/science.aar7201.Peer-Reviewed Original ResearchConceptsGut pathobiontAutoimmune-prone miceMurine findingsIntramuscular vaccinePathogenic autoantibodiesLiver biopsyAutoimmune responseAutoimmune patientsAntibiotic treatmentT cellsImmune diseasesAutoimmunitySusceptible humansPathobiontsSystemic tissuesHuman hepatocytesAutoantibodiesMortalityMiceCocultureHepatocytesGenetic backgroundTissueBiopsyPatients